Sirt5 conditional Knockout mouse

Target

Gene symbol :

Sirt5

NCBI gene ID :

68346

Gene full name :

Sirtuin 5

Synonym :

SIR2L5

Protein function

Protein name :

NAD-dependent protein deacylase sirtuin-5

Regulates mitochondrial metabolism via lysine desuccinylation and demalonylation; involved in energy homeostasis and ammonia detoxification

Expected phenotype

Disruption affects ammonia detoxification; elevated blood ammonia under fasting or high-protein diet

Human disease relevance

Linked to metabolic disorders and cancer metabolism regulation

Model applications

Used to study mitochondrial metabolism, ammonia detoxification, and cancer metabolism

Keywords:

Mitochondria, Metabolism, Cancer, Detoxification

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Sirt5

conditional Knockout mouse

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