Smurf1 conditional Knockout mouse

Target

Gene symbol :

Smurf1

NCBI gene ID :

75788

Gene full name :

SMAD specific E3 ubiquitin protein ligase 1

Synonym :

Smurf-1

Protein function

Protein name :

E3 ubiquitin-protein ligase SMURF1

Ubiquitin ligase targeting SMADs and RhoA; modulates TGF-β and BMP signaling

Expected phenotype

Knockouts display altered osteogenesis and skeletal patterning

Human disease relevance

Implicated in cancer metastasis and bone development

Model applications

Studied in TGF-β/BMP signaling, bone biology, and cancer

Keywords:

E3 ligase, TGF-β, BMP, Ubiquitin, Bone development

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Smurf1

conditional Knockout mouse

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