Smurf2 conditional Knockout mouse

Target

Gene symbol :

Smurf2

NCBI gene ID :

66313

Gene full name :

SMAD specific E3 ubiquitin protein ligase 2

Synonym :

Smad ubiquitination regulatory factor 2

Protein function

Protein name :

SMURF2

E3 ubiquitin ligase that regulates TGF-β signaling via SMAD degradation.

Expected phenotype

Abnormal SMAD signaling

Human disease relevance

Implicated in cancer, fibrosis, and immune regulation

Model applications

Ubiquitin pathway, TGF-β signaling

Keywords:

Ubiquitin, SMAD, TGF-beta

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Smurf2

conditional Knockout mouse

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