Syk conditional Knockout mouse

Target

Gene symbol :

Syk

NCBI gene ID :

20963

Gene full name :

Spleen tyrosine kinase

Synonym :

SYK tyrosine kinase

Protein function

Protein name :

SYK

Non-receptor tyrosine kinase; key in B-cell receptor signaling and Fc receptor activation

Expected phenotype

B-cell and platelet defects, immunodeficiency

Human disease relevance

Linked to immunodeficiencies, autoimmune disorders, leukemia

Model applications

Immunity, allergy, hematopoietic studies

Keywords:

Tyrosine kinase, Immunoreceptor signaling

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Syk

conditional Knockout mouse

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Models with certified health status from professional breeders in US and Europe