Tor1aip1 conditional Knockout mouse

Target

Gene symbol :

Tor1aip1

NCBI gene ID :

208263

Gene full name :

Torsin 1A interacting protein 1

Synonym :

Lamina-associated polypeptide 1 (LAP1)

Protein function

Protein name :

LAP1 protein

Nuclear envelope protein interacting with torsinA; involved in nuclear-cytoskeletal coupling

Expected phenotype

Knockouts show nuclear envelope abnormalities and motor defects

Human disease relevance

Mutations cause muscular dystrophy and dystonia-like symptoms

Model applications

Studied in nuclear architecture and neuromuscular disorders

Keywords:

Nuclear envelope, LAP1, TorsinA, Dystonia, Laminopathy

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Tor1aip1

conditional Knockout mouse

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