Trp53bp2 conditional Knockout mouse

Target

Gene symbol :

Trp53bp2

NCBI gene ID :

209456

Gene full name :

Tumor protein p53 binding protein 2

Synonym :

ASPP2

Protein function

Protein name :

Apoptosis-stimulating of p53 protein 2

Enhances p53-mediated apoptosis by promoting transcription of pro-apoptotic genes

Expected phenotype

Knockouts show resistance to apoptosis and increased tumorigenesis

Human disease relevance

Downregulated in multiple cancers; regulates tumor suppressor pathways

Model applications

Studied in p53 signaling, apoptosis, and cancer biology

Keywords:

Apoptosis, p53 signaling, Tumor suppressor, ASPP family

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Trp53bp2

conditional Knockout mouse

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