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IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell-mediated cytotoxicity of PD-L1 positive tumor cells

Scientific article

IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell-mediated cytotoxicity of PD-L1 positive tumor cells

Desbois M
IGM Biosciences
May 22, 2025
Cancer Immunol Res
https://pubmed.ncbi.nlm.nih.gov/40402523/

This article is currently being updated. View its version on PubMed.

https://pubmed.ncbi.nlm.nih.gov/40402523/

Research summary

The study investigates IGM-7354, an IL-15/IL-15Rα fused IgM that targets PD-L1 and activates NK and CD8+ T cells. In vivo efficacy and immune engagement were evaluated.

Key outcome of the study

IGM-7354 successfully engages and expands cytotoxic immune subsets and reduces tumor burden in a HIS mouse model.

Model

Humanized BRGSF-HIS mouse model developed by genOway

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Keywords

Immuno-oncology, PD-L1 targeting, IL-15 immunotherapy, human immune system mouse models

Technical specifications

Humanized model, BRGSF-HIS, IL-15 fusion, PD-L1 targeting, IgM

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genO‑BRGSF‑HIS mice possess the most functional reconstituted human immune system currently on the market and are highly relevant for translational research.

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