R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System

Gonzalo Garcia-Martin
Universidad Autónoma de Madrid
December 9, 2021
Int J Mol Sci
https://pubmed.ncbi.nlm.nih.gov/35055164

This article is currently being updated. View its version on PubMed.

https://pubmed.ncbi.nlm.nih.gov/35055164

Research summary

This study investigates the expression patterns of R-Ras1 and R-Ras2 in the central nervous system. Using transcriptomic and reporter analysis along with conditional Knockout models, the study demonstrates distinct regional and cell-type-specific expression profiles, suggesting non-redundant roles in CNS development and function.

Key outcome of the study

R-Ras1 and R-Ras2 exhibit different expression profiles in neurons, astrocytes, and oligodendrocytes, pointing to divergent functions in neural development and maintenance.

Mouse model

Conditional Rras1 Knockout mouse model developed by genOway, allowing tissue-specific inactivation via Cre-loxP system. Used alongside Rras2 expression analysis to map roles in neural tissues.

TARGET:
Rras
R-Ras1

Keywords

Neurobiology, CNS development, Neuron signaling, Gene expression mapping

Technical specifications

Conditional Knockout, Cre-loxP, Cell-specific gene deletion

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