This study investigates the expression patterns of R-Ras1 and R-Ras2 in the central nervous system. Using transcriptomic and reporter analysis along with conditional Knockout models, the study demonstrates distinct regional and cell-type-specific expression profiles, suggesting non-redundant roles in CNS development and function.
R-Ras1 and R-Ras2 exhibit different expression profiles in neurons, astrocytes, and oligodendrocytes, pointing to divergent functions in neural development and maintenance.
Conditional Rras1 Knockout mouse model developed by genOway, allowing tissue-specific inactivation via Cre-loxP system. Used alongside Rras2 expression analysis to map roles in neural tissues.
Neurobiology, CNS development, Neuron signaling, Gene expression mapping
Conditional Knockout, Cre-loxP, Cell-specific gene deletion
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
