This study characterizes SDRG immunodeficient rats on a Sprague Dawley background with targeted deletion of Rag1 and Il2rg between 10 and 26 weeks of age. Hematology showed markedly reduced lymphocytes with increased neutrophils, monocytes and eosinophils. Clinical chemistry differences included increased urea and cholesterol and decreased albumin and total protein. Immunophenotyping confirmed absence of B cells, T cells and NK cells. Histopathology revealed lymphoid organ hypoplasia, inflammatory changes in kidney and lung, and age related cardiomyopathy and nephropathy. These findings provide baseline pathology data for this immunodeficient model.
SDRG rats lack B cells, T cells and NK cells and display predictable hematologic and biochemical alterations. Background inflammatory and degenerative lesions were documented to guide interpretation of preclinical studies.
SDRG rats lack B cells, T cells and NK cells and display predictable hematologic and biochemical alterations. Background inflammatory and degenerative lesions were documented to guide interpretation of preclinical studies.
Immunodeficient rat model, immuno oncology, cell therapy testing, baseline pathology characterization, translational disease modeling
Targeted deletion of Rag1 and Il2rg on Sprague Dawley background, hematology and clinical chemistry panels, flow cytometry immune profiling, gross necropsy, histopathology evaluation across age groups
From model design to experimental results
Featured in 600+ scientific articles
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170+ Biotechs and 380+ Academic Institutions
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Models with certified health status from professional breeders in US and Europe
