This study investigates the immune response in individuals with peanut allergy, focusing on the convergence of monoclonal IgE antibodies to a specific epitope on the Ara h 2 protein, which is known to trigger anaphylactic reactions. The research aims to understand the molecular basis of this convergence and its implications for allergy diagnostics and therapeutics.
The findings reveal that individuals with peanut allergy commonly produce IgE antibodies targeting a specific epitope on the Ara h 2 protein. Using the humanized mouse model, researchers demonstrated that IgE antibodies binding to this epitope could trigger severe systemic anaphylaxis, highlighting its potential as a therapeutic target.
Humanized IgE and FcεRI mouse model developed by genOway, in which the murine IgE and FcεRI genes are replaced with their human counterparts. This model enables the functional study of human IgE-mediated anaphylaxis in vivo.
Peanut allergy, IgE-mediated hypersensitivity, Anaphylaxis, Immunotherapy, FcεRI signaling
Humanized Knockin mouse model, IgE-FcεRI axis, Anaphylaxis model, Passive sensitization, Epitope mapping
From model design to experimental results
Featured in 600+ scientific articles
Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions
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Models with certified health status from professional breeders in US and Europe
