Enhance the translatability of the immune/efficacy-related effects of biologics using one humanized mouse model

October 20, 2026

Duration: 31 min

Content

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▶️ genO-BRGSF-HIS mice recapitulate key CRS features induced by biologics tested in the clinic

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▶️ Immune cells are recruited, polarized and activated in the tumor microenvironment in genO-BRGSF-HIS mice

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▶️ genO-BRGSF-HIS enables the assessment of both efficacy and safety in a single model

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Speaker

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Fabiane Sônego, PhD in Immunology and Pharmacology, is the Director of Preclinical Models and Services at genOway. She has extensive expertise in in vivo models for immuno-oncology and inflammation and a proven track record of supporting researchers in advancing translational research and accelerating drug development.

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Enhance the translatability of the immune/efficacy-related effects of biologics using one humanized mouse model

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genO-BRGSF-HIS

genO‑BRGSF‑HIS mice possess the most functional reconstituted human immune system currently on the market and are highly relevant for translational research.

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