genO‑BRGSF‑HIS mouse model

The genO‑BRGSF‑HIS mouse possesses the most functional reconstituted human immune system currently available on the market. Indeed, this mouse, based on the cutting edge genO-BRGSF model, offers new opportunities to address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.

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Applications of the genO‑BRGSF‑HIS mouse model

The genO‑BRGSF‑HIS mouse model can address a broad spectrum of therapeutic areas and applications, including bispecific antibodies, immuno-oncology, infectiology, vaccines, drug screening, and personalized medicine.

• ‍Application in tumor biology:
  • Assessment of myeloid and lymphoid human cells recruitment and activation profile into the tumor microenvironment (TME) shaped by tumor cell type and tumor burden

• ‍Application in efficacy assessment of:
  • T-cell engagers
  • Myeloid-targeted therapies aiming at reprogramming the TME
  • Depleting agents working via ADCP and ADCC
  • γδ T-cell expanders, as the model has shown to develop different subsets of γδ T cells

• ‍Application in safety assessment of:‍
  • Anti-CD3 OKT3 antibody which targets the lymphoid and/or myeloid compartments, demonstrating the development of the hallmark features of cytokine release syndrome, as well as CRS-associated features induced by T-cell or myeloid targeting agents. The OKT3-induced CRS features could be alleviated by Infliximab
  • Anti-VISTA pH-selective antibody, showing the safety of SNS-101 therapeutic antibody