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Design of the hCD28 mouse
The humanized CD28 model, developed by Knockin at the mouse CD28 locus, expresses a chimeric CD28 with a human extracellular and murine transmembrane and intracellular domains. The design also gives access to CD28 conditional Knockout mice.
hCD28 features
- The CD28 extracellular domain is entirely humanized
- Physiological regulation and expression pattern of the human CD28
- Fully functional mouse immune system
- Lack of expression of the murine target gene, thus avoiding cross-reactivity
Clients
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