Design of the hGITR mouse

The humanized GITR mouse model (hGITR) is developed by Knockin at the mouse GITR locus and driven by the endogenous promoter. It expresses a chimeric GITR with a human extracellular and murin intracellular domain. The human isoforms display diversity within the intracellular domain, and are expressed in case they support different signaling functions.

hGITR features

  • The GITR extracellular domain is entirely humanized
  • Physiological regulation and expression pattern of the human GITR
  • Fully functional mouse immune system
  • Lack of expression of the murine target gene, thus avoiding cross-reactivity

Validation

Related resources and publications

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