Design of the hCD39 mouse

The humanized CD39 model, developed by Knockin at the mouse CD39 locus, expresses a chimeric CD39 with a human extracellular and murine transmembrane and intracellular domains. The design also gives access to CD39 conditional Knockout mice.

The human CD39 expression recapitulates murine CD39 expression. hCD39 is functional:  α-human CD39 specifically reduces human CD39 activity.

hCD39 features

  • The CD39 extracellular domain is entirely humanized
  • Physiological regulation and expression pattern of the human CD39
  • Fully functional mouse immune system
  • Lack of expression of the murine target gene, thus avoiding cross-reactivity

Validation

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