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genO-hGLP‑1R
Humanized mice (target-specific)

Preclinical humanized genO‑hGLP-1R mouse model

Preclinical genO‑hGLP-1R model for assessment of agents targeting human GLP-1R

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Applications of the genO‑hGLP-1R mouse model

Broad range of applications in the fields of metabolism, autoimmunity and neuroscience:

  • Assess the efficacy of GLP-1R targeting compounds, such as in the context of treating type 2 diabetes and obesity
  • Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential

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Features

  • Physiological regulation and expression of the humanized GLP-1R
  • Fully functional hGLP-1R
  • Lack of expression of the murine target gene
  • Model is available in a C57BL/6N background
  • Fully functional mouse immune system

Clients

Pfizer

Scientific articleScientific articlePosterPoster

Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Validation data

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genO-hGLP‑1R

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Preclinical humanized genO‑hGLP-1R mouse model

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Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

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Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

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Innovative technologies

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Easy access to models

Models with certified health status from professional breeders in US and Europe