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genO-hTFRC
Humanized mice (target-specific)

Preclinical humanized genO‑hTFRC mouse model

The fully immunocompetent genO‑hTFRC mouse model enables in vivo efficacy assessment and profiling of compounds targeting human TFRC (CD71, TfR1) and aiming to deliver therapeutic agents through the blood brain barrier.

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Applications of the genO‑hTFRC mouse model

Useful applications for researchers working on different biomedical fields, such as neuroscience, immuno-oncology and inflammation:

  • Improve the delivery of therapeutic agents aiming to cross the blood-brain barrier (BBB), via human transferrin receptor (TFRC) binding and test their efficacy
  • Assess the efficacy of immunotherapies in cancers that overexpress TFRC (CD71, TfR1)
  • Evaluate the in vivo PK profile and toxicity of TFRC-binding therapeutics

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Features

  • Physiological regulation and expression pattern of human TFRC
  • Lack of expression of the murine target gene
  • Fully functional mouse immune system
  • Available on C57BL/6N genetic background

Clients

Lundbeck

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Inatherys

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Customize this model

Tailor this model to meet your research needs:

  • Assess the efficacy and safety of therapeutics with multiple humanized targets
  • Simultaneously evaluate efficacy, safety, and PK in a single model
  • Assess the impact of the human Fc-domain of an antibody while assessing its efficacy and safety
  • Increase tolerance to human IgG1

…and more to fit your program

Model Delivery & Care

  • Read our FAQ on delivery & care here
  • Orders are made directly with genOway; breeding, housing and delivery are outsourced
  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders

Baseline validation

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Preclinical humanized genO‑hTFRC mouse model

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Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

Generated with biopharma partners and in-house

Innovative technologies

and guaranteed freedom to operate

Easy access to models

Models with certified health status from professional breeders in US and Europe