Genetically Engineered Cell Lines

Our CRISPR/Cas9 gene-editing platform for customized cell line development is optimized for mammalian and human cells.

A major benefit for you and your research is our rigorous procedure to quickly evaluate the feasibility of using your proper cell line. Our genetic modifications to your chosen in-house cell line optimize the use of your existing data and avoid the need for new standardization experiments.

We ensure reliable and reproducible performance in murine or human:

  • Cancer, cardiovascular disease, diabetes, respiratory, and musculoskeletal cell lines
  • Embryonic stem, induced pluripotent stem, neural stem cell, and more

 

Our cell line services

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Constitutive Knockouts
Permanent inactivation of the target gene, and total absence of the protein
Point mutation Knockins
One or more constitutively mutated nucleotides affecting the function of a given protein (gain/loss of function)
Reporter Knockins
With inserted fluorescent, bioluminescent proteins or biochemical tags
Quick Knockin™
Controlled gene expression by targeting permissive loci Rosa26, Hprt or AAVS1
"Simple" Knockin
Add a gene sequence of interest to an endogenous locus

 


 

Learn more about our cell line engineering service:

 

 

Follow this link if you are looking for another transgenic model.