Design of the hOX40 mouse

The humanized OX40 mouse model (hOX40) is developed by Knockin at the mouse OX40 locus, and expresses a fully humanized OX40 with a human extracellular, transmembrane and intracellular domain.

hOX40 features

  • Physiological regulation and expression pattern of the human OX40
  • Preservation of the target-ligand interaction
  • Fully functional mouse immune system
  • Lack of expression of the murine target gene, thus avoiding cross-reactivity

Anti-tumor efficacy and tumor-specific immunological memory were proven in MC38 and MB49 tumor models.

Validation

Related resources and publications

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