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Application of the hOX40 mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, immuno-inflammation and autoimmunity:
- Efficacy assessment of OX40-targeting compounds, such as in tumor growth inhibition assays
- Evaluation of OX40 antagonists for the treatment of autoimmune and inflammatory conditions
- The hOX40 model supports long-term studies as immunological memory is observed following treatment
- Gaining insights into the mode of action (MoA) of diverse constructs and their potential therapeutic benefits
Features
- Physiological regulation and expression pattern of the human OX40
- Preservation of the target-ligand interaction
- Fully functional mouse immune system
- Lack of expression of the murine target gene, thus avoiding cross-reactivity
Anti-tumor efficacy and tumor-specific immunological memory were proven in MC38 and MB49 tumor models.
