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genO-hIL-18/hIL-18R
Humanized mice (target-specific)

Preclinical Double Humanized genO‑hIL-18/hIL-18R Mouse Model

The double-humanized genO‑hIL-18/hIL-18R model provides new opportunities for in vivo assessment of IL-18-based therapies.

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Applications of the genO‑hIL-18/hIL-18R mouse model

Useful applications for researchers working on different biomedical fields, such as inflammation and autoimmunity:

  • Assess the efficacy of IL-18–based therapies
    • Analyze the tumor microenvironment composition following treatment with IL-18-based therapies
    • Perform tumor growth inhibition assays in the context of combotherapies
    • Identify new possible therapies
  • Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits

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Features

  • Physiological regulation and expression pattern of humanized IL-18 and IL-18 receptor (IL-18R)
  • Preservation of the target-ligand interactions
  • Conservation of the IL-18 downstream signaling
  • Fully functional mouse immune system
  • Lack of expression of the murine target genes

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Customize this model

Tailor this model to meet your research needs:

  • Assess the efficacy and safety of therapeutics with multiple humanized targets
  • Simultaneously evaluate efficacy, safety, and PK in a single model
  • Assess the impact of the human Fc-domain of an antibody while assessing its efficacy and safety
  • Increase tolerance to human IgG1

…and more to fit your program

Model Delivery & Care

  • Read our FAQ on delivery & care here
  • Orders are made directly with genOway; breeding, housing and delivery are outsourced
  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders

Baseline validation

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Preclinical Double Humanized genO‑hIL-18/hIL-18R Mouse Model

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Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

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Innovative technologies

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Easy access to models

Models with certified health status from professional breeders in US and Europe