Applications of the genO‑hCTLA‑4 mouse model

Useful applications for researchers working on different biomedical fields, such as immuno-oncologyinflammation and autoimmunity:

  • Assess the efficacy of CTLA-4-targeting therapeutics
    • Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
  • Investigate the mode of action (MoA) of CTLA-4-targeting compounds and understand their therapeutic potential
  • Evaluate the safety and toxicity of compounds
  • The genO‑hCTLA‑4 model supports long-term studies as immunological memory is observed following treatment

Features

  • Expression of different hCTLA-4 isoforms
  • Physiological regulation and expression pattern of the human CTLA-4
  • Preservation of the target-ligand interaction
  • Fully functional mouse immune system
  • Lack of expression of the murine target gene, thus avoiding cross-reactivity
  • The genO‑hCTLA‑4 model is designed to enable the easy generation of a CTLA-4 conditional Knockout mouse for tissue-specific assessment of compounds’ specificity and toxicity

Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Validation data

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genO-hCTLA‑4

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Preclinical humanized genO‑hCTLA-4 mouse model

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Models with certified health status from professional breeders in US and Europe