(argenx) Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling

Humanized Mouse Model of Fcγ Receptors

FASEB 2024

August 30, 2024

Summary

We present a cross-species FcγR atlas and a humanized mouse model with refined humanized FcγR expression and antibody pharmacokinetics which will improve the preclinical assessment of antibody-based therapeutics.

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Related products

Catalogue product

genO-hFcγR

Preclinical humanized Fc-gamma receptor (genO‑hFcγR) model enabling the in vivo assessment of Fc receptor-targeted therapies.

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genO-hFcγR/hFcRn

Double-humanized genO‑hFcγR/hFcRn mouse model to improve PK and efficacy assessment of compounds with extended half-life through FcRn binders.

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Customized product

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Scientific excellence

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Models with certified health status from professional breeders in US and Europe

Humanized targets