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Design of the genO-CT26-hPD-L1 cell line
The CT26.WT cell line was derived and subcloned from Balb/c murine colon carcinoma and forms tumors at high frequency when inoculated subcutaneously. We generated a genO-CT26‑hPD‑L1 clonal cell line expressing human PD‑L1.
Applications in immuno-oncology
As for our genO-MC38-hPD-L1 cell line, the genO-CT26-hPD-L1 cell line can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.
genO-CT26-Pd-l1KO tumor cell line:
Use our genO-CT26-Pd-l1KO clones for target validation and mechanistic studies.
Features
We generated a genO-hCT26-hPD-L1 clonal cell line expressing high levels of human PD-L1, and forming solid tumors in vivo.
- They only express human PD-L1, as they are invalidated for murine Pd‑l1
- hPD-L1 is entirely humanized
- Strong and sustained expression of human PD-L1
Clients
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