Design of the CT26-hCD39-LZ cell line

The CT26-hCD39-LZ clonal cell line expresses high levels of a human/mouse chimeric CD39, and forms solid tumors in vivo. An optimized version of a luciferase-ZsGreen (LZ) fusion protein is also stably expressed for in vivo imaging and ex vivo tracking.

This cell line can be used in syngeneic models with our huCD39 mouse model.

CT26-hCD39-LZ features

  • Express a functional chimeric CD39 with a fully humanized extracellular domain
  • Express a luciferase-ZsGreen (LZ) fusion reporter
  • Form solid tumors upon subcutaneous injection in fully immunocompetent mice
  • Injected cells can be followed in vivo and ex vivo with our LZ reporter

Validation

Related resources and publications

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