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genO-MC38-hPD-L1-hFAP-LZ
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genO-MC38-hPD-L1-hFAP-LZ cell line for anti-tumor efficacy assessment

The genO-MC38-hPD-L1-hFAP-LZ clonal cell line expresses human PD-L1, human FAP and an optimized dual fusion reporter, luciferase-ZsGreen (LZ)

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Design of the genO-MC38-hPD-L1-hFAP-LZ cell line

The MC38 cell line was derived from C57BL/6 murine colon adenocarcinoma cells. They form solid tumors upon subcutaneous injection in immunocompetent mice.

We generated a genO-MC38-hPD-L1-hFAP-LZ clonal cell line expressing human PD-L1 (CD274 NCBI GeneID: 29126), human FAP (NCBI GeneID: 2191) and an optimized dual fusion reporter, luciferase-ZsGreen (LZ). These cells are invalidated for murine Pd-l1 (Cd274, NCBI Gene ID: 60533). genO-MC38-hPD-L1-hFAP-LZ cells form solid tumors in vivo. Isogenic luciferase-ZsGreen (LZ) cells are available.

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Features

  • Express high levels of full human PD-L1 and FAP
  • Express a luciferase-ZsGreen (LZ) fusion reporter
  • Form solid tumors upon subcutaneous injection in fully immunocompetent mice
  • Injected cells can be followed in vivo and ex vivo with our LZ reporter

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Reannotation of cancer mutations based on expressed RNA transcripts reveals functional non-coding mutations in melanoma

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ERα-36 regulates progesterone receptor activity in breast cancer

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