Design of the CT26-Pd‑l1 Knockout

The CT26.WT cell line was derived and subcloned from Balb/c murine colon carcinoma and forms tumors at high frequency when inoculated subcutaneously. We generated CT26-Pd-l1 Knockout clonal cell lines invalidated for murine Pd-l1 (Cd274).

Applications in immuno-oncology

The CT26-Pd-l1 Knockout clones can be used for target validation and mechanistic studies.

Humanized CT26-hPD-L1 cell line:
Use our humanized CT26-hPD-L1 cell line for in vivo tumor growth assays in syngeneic models.

CT26-Pd-l1 Knockout features

  • Invalidated for murine Pd-l1
  • Form tumors upon subcutaneous injection in fully immunocompetent mice

Validation

Related resources and publications

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