Related resources and publications
Targeting the human CD47/SIRPα axis
Humanized ICP mouse and cell lines
Front Immunol
PLoS One
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The CT26-hCD39-LZ clonal cell line expresses high levels of human/mouse chimeric CD39, and forms solid tumors in vivo.
The CT26-hCD39-LZ clonal cell line expresses high levels of a human/mouse chimeric CD39, and forms solid tumors in vivo. An optimized version of a luciferase-ZsGreen (LZ) fusion protein is also stably expressed for in vivo imaging and ex vivo tracking.
This cell line can be used in syngeneic models with our huCD39 mouse model.
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Expression analysis by flow cytometry. Chimeric CD39 is detected with anti-human CD39 (Biolegend clone A1).
hCD39 Balb/c mice were injected (s.c.) with 1x106 CT26-chimCD39-LZ cells. Tumor growth was measured every 2 to 3 days. Tumor size (mm3) = (width2 x length)/2.
Targeting the human CD47/SIRPα axis
Humanized ICP mouse and cell lines
Front Immunol
PLoS One
Immunology
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