Home
Off-the-shelf
Cell lines
genO-MC38-hPD-L1-hHER2-LZ
Cell lines

Humanized genO-MC38-hPD-L1-hHER2-LZ reporter tumor cell line

The genO-MC38-hPD-L1-hHER2-LZ clonal cell line expresses high levels of human PD-L1  and human HER2.

Contact Us

Design of the genO-MC38-hPD‑L1-hHER2-LZ cell line

The MC38 cell line was derived from C57BL/6 murine colon adenocarcinoma cells. They form solid tumors upon subcutaneous injection in immunocompetent mice.

We generated a genO-MC38-hPD-L1-hHER2-LZ clonal cell line expressing high levels of human PD-L1 (CD274 NCBI GeneID: 29126) and human HER2 (ERBB2 NCBI GeneID: 2064), and an optimized dual fusion reporter luciferase-ZsGreen (LZ). These cells are invalidated for murine Pd-l1 (Cd274, NCBI Gene ID: 60533). genO-MC38-hPD-L1-hHER2-LZ cells form solid tumors in vivo. Isogenic wild-type (WT) and luciferase-ZsGreen (LZ) control clones are available.

‍

Features

  • Express high levels of full human PD-L1 and HER2
  • Express a luciferase-ZsGreen (LZ) fusion reporter
  • Form solid tumors upon subcutaneous injection in fully immunocompetent mice
  • Injected cells can be followed in vivo and ex vivo with our LZ reporter

Clients

No items found.

Related resources and publications

Adult-type granulosa cell tumor (AGCT)

castration-resistant metastatic prostate cancer (mCRPC)

CCR8

Chemokine

SIRPα

sirp-alpha

CD137

pulmonary embolism (PE)

osteomyelitis

hyperalgesia

PET imaging

intrauterine growth deficiency

Myopia

ossification

cGAS

cGAS-STING pathway

TFRC

FX-deficiency

muscle-eye-brain disease (MEB)

Tumor microenvironment

primary immunodeficiency (PID)

Oncology

Pharmacology

Neuroscience

Metabolism

Inflammation

Immunology

Respiration

Cardiovascular

Ophthalmology

Nephrology

Musculoskeletal

Hematology

Epigenetics

Development

Endocrinology

Dermatology

Humanization

Rosa26

TET system

Hprt

CreERt2

FLEx

innate immunity

Transgenesis

infection

vision

immune response

dementia

central nervous system (CNS)

taste

transplantation

autoimmunity

thermoregulation

sugar homeostasis

stress

skelet

pulmonary research

nutrition

pain research

muscle research

locomotion

memory

hearing

fat homeostatsis

tissue research

epigentic modification

drugs

cancer research

cell research

behavior

aging

stem cell research

reproductive research

lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

blood research

von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

small cell lung cancer

SHORT syndrome

sepsis

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
PosterS
(
0
)
Scientific Articles
(
0
)
CommentarIes
(
0
)
Case studies
(
0
)
No results
Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

Front Immunol

Dec 2023
Highlighted article
read the comment
CCX559 is a potent orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

PLoS One

Apr 2023
Highlighted article
read the comment
ERα-36 regulates progesterone receptor activity in breast cancer

Breast Cancer Res

Aug 2020
T cells expressing a chimeric-PD1-Dap10-CD3zeta receptor reduce tumor burden in multiple murine syngeneic models of solid cancer

Immunology

Mar 2020
Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF

Cancer Immunol Res

Oct 2019
SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.

Nat Immunol

Aug 2019
Development of a new hSIRPα-specific radiotracer for non-invasive PET imaging using genOway’s double humanized genO-hCD47/hSIRPα mouse and genO-MC38-hPD-L1-hCD47-LZ cell line

Targeting the human CD47/SIRPα axis

10 min read
-
Mar 2024
CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

Humanized ICP mouse and cell lines

9 min read
-
Jun 2023
A new promising family of small molecules regulating the PD-L1/PD-1 signaling pathway

Humanized PD-1/PD-L1 mouse and cell line

10 min read
-
Jul 2022
Improving in vitro models: the coming of age of organoids

Organoids

6 min read
-
Mar 2018
iPS technology: Four factors that will change the world… some day

iPS technology

5 min read
-
Nov 2017
No results
No results

Validation data

Discover related products to

genO-MC38-hPD-L1-hHER2-LZ

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Immune checkpoint
PD-1
PD-L1
ICP (multi-target)

genO-hPD‑1/hPD‑L1

The genO‑hPD-1/hPD-L1 mouse model enables in vivo efficacy assessment and profiling of molecules targeting the human PD-1/PD-L1 axis in fully immunocompetent mice.

Immune checkpoint
PD-L1
CT26

genO-CT26-Pd-l1KO

The Pd-l1 Knockout colon carcinoma CT26 cell line is invalidated for murine Pd-l1 and can be used for target validation and mechanistic studies.

CT26
Immune checkpoint
CD39

genO-CT26-hCD39-LZ

The genO-CT26-hCD39-LZ clonal cell line expresses high levels of human/mouse chimeric CD39, and forms solid tumors in vivo.

CT26
Immune checkpoint
EpCAM

genO-CT26-hEpCAM-LZ

genO-CT26-hEpCAM-LZ clonal cell line expresses high levels of human EpCAM, and forms solid tumors in vivo.

CD19
EL4
Immune checkpoint

genO-EL4-hCD19-LZ

genO-EL4-hCD19-LZ cells form tumors in syngeneic models, upon subcutaneous and systemic (i.v.) injection, in immunocompetent mice.

CD20
Immune checkpoint
EL4

genO-EL4-hCD20-LZ

The genO-EL4-hCD20-LZ clonal cell line expresses high levels of human CD20.

PD-L1
Immune checkpoint

genO-MC38-Pd-l1KO

The Pd-l1 Knockout colon adenocarcinoma MC38 cell line is invalidated for murine Pd-l1 and can be used for target validation and mechanistic studies.

CD39
MC38
Immune checkpoint

genO-MC38-hCD39-LZ

The genO-MC38-hCD39-LZ cells homogeneously express human CD39 in vitro, and form infiltrated tumors in immunocompetent mice.

PD-L1
Immune checkpoint
MC38
PD-1

genO-MC38-hPD-L1-LZ

The genO-MC38-hPD-L1-LZ clonal cell line expresses high levels of  human PD-L1 and forms solid tumors in vivo. An optimized version of a  luciferase-ZsGreen (LZ) fusion protein is also stably expressed for in vivo imaging and ex vivo tracking.

MC38
Immune checkpoint
PD-L1
CD47

genO-MC38-hPD‑L1-hCD47-LZ

The genO‑MC38-hPD-L1-hCD47-LZ clonal cell line expresses high levels of human PD-L1 and human CD47.

PD-L1
Immune checkpoint
CT26

genO-hCT26-hPD‑L1

The humanized hPD-L1 syngeneic clonal colon carcinoma CT26 cell line expresses high levels of human PD-L1 and forms solid tumors in vivo.

Humanized genO-MC38-hPD-L1-hHER2-LZ reporter tumor cell line

Get in touch about

Let us know how we can help