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Applications of the genO‑hCD28 mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, inflammation and autoimmunity:
- Assess the efficacy of CD28-targeting therapeutics or of other immune checkpoint inhibitors
- Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
- Evaluate the safety and toxicity of compounds
- Study CNS-related autoimmune diseases since genO-hCD28 model develops experimental autoimmune encephalomyelitis (EAE)
- Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential
Features
- Physiological regulation and expression pattern of hCD28
- Expression of different hCD28 isoforms
- Fully functional mouse immune system
- Lack of expression of the murine target gene, thus avoiding cross-reactivity
Clients
