Design of the EL4-hCD20-LZ cell line

The EL-4 cell line was established from a C57BL/6 murine lymphoma. These cells form tumors in syngeneic models, upon subcutaneous and systemic (i.v.) injection, in immunocompetent mice.

We generated an EL4-hCD20-LZ clonal cell line expressing high levels of human CD20 (MS4A1 NCBI GeneID: 931), and an optimized dual fusion reporter luciferase-ZsGreen (LZ). EL4-hCD20-LZ cells form tumors in vivo when injected systemically. Luciferase-ZsGreen (LZ) control cells are available.

‍

EL4-hCD20-LZ features

  • Express a fully human CD20
  • Express a luciferase-ZsGreen (LZ) fusion reporter
  • Form tumors and impact survival upon systemic injection in fully immunocompetent mice
  • Luciferase from injected cells can be detected by in vivo imaging

Validation

Related resources and publications

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
No results

Discover related products to

EL4-hCD20-LZ

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Cells
PD-L1
ICP
Humanized targets
MC38

MC38-hPD-L1-LZ

The MC38-hPD-L1-LZ clonal cell line expresses high levels of  human PD-L1 and forms solid tumors in vivo. An optimized version of a  luciferase-ZsGreen (LZ) fusion protein is also stably expressed for in vivo imaging and ex vivo tracking.

Cells
MC38
ICP
Reporter
PD-L1

MC38-hPD-L1-hHER2-LZ

The  MC38-hPD-L1-hHER2-LZ clonal cell line expresses high levels of human PD-L1  and human HER2.

CD39
Cells
MC38
Humanized targets
Reporter

MC38-hCD39-LZ

The  MC38-hCD39-LZ cells homogeneously express human CD39 in vitro, and form  infiltrated tumors in immunocompetent mice.

CD19
EL4
Humanized targets
Cells
ICP

EL4-hCD19-LZ

EL4-hCD19-LZ cells form tumors in syngeneic models, upon subcutaneous and systemic (i.v.) injection, in immunocompetent mice.

CT26
Cells
ICP
Humanized targets
EpCAM

CT26-hEpCAM-LZ

CT26-hEpCAM-LZ  clonal cell line expresses high levels of human EpCAM, and forms solid tumors in vivo.

CT26
Cells
ICP
Humanized targets
CD39

CT26-hCD39-LZ

The CT26-hCD39-LZ clonal cell line expresses high levels of human/mouse chimeric CD39, and forms solid tumors in vivo.

ICP
PD-L1
Knockout
Cells
CT26

CT26-Pd-l1-ko

The Pd-l1 Knockout colon carcinoma CT26 cell line is invalidated for murine Pd-l1 and can be used for target validation and mechanistic studies.

Cells
MC38
ICP
Reporter
PD-L1

MC38-hPD-L1-hCD47-LZ

The MC38-hPD-L1-hCD47-LZ clonal cell line expresses high levels of human PD-L1 and human CD47.

Humanized EL4-hCD20-LZ reporter tumor cell line

Get in touch about

Let us know how we can help

In order to provide you the content requested, we need to store and process your personal data. If you consent to us storing your personal data for this purpose, please tick the checkbox below.

From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you. If you consent to us contacting you for this purpose, please tick below.

You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.