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genO-MC38-hEpCAM-LZ
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Humanized genO-MC38-hEpCAM-LZ reporter tumor cell line

The genO-MC38-hEpCAM-LZ clonal cell line expresses human EpCAM (NCBI GeneID: 4072), and an optimized dual fusion reporter, luciferase-ZsGreen (LZ)

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Design of the genO-MC38-hEpCAM-LZ cell line

The MC38 cell line was derived from C57BL/6 murine colon adenocarcinoma cells. They form solid tumors upon subcutaneous injection in immunocompetent mice.

We generated a genO-MC38-hEpCAM-LZ clonal cell line expressing human EpCAM (NCBI GeneID: 4072), and an optimized dual fusion reporter, luciferase-ZsGreen (LZ). genO-MC38-hEpCAM-LZ cells form solid tumors in vivo. Isogenic luciferase-ZsGreen (LZ) cells are available.

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Features

  • Express high levels of full human EpCAM
  • Express a luciferase-ZsGreen (LZ) fusion reporter
  • Form solid tumors upon subcutaneous injection in fully immunocompetent mice
  • Injected cells can be followed in vivo and ex vivo with our LZ reporter

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Validation data

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Humanized genO-MC38-hEpCAM-LZ reporter tumor cell line

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