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genO-hICOS
Humanized mice (target-specific)

Preclinical Humanized genO-hICOS Mouse Model

The genO-hICOS mouse enables the in vivo efficacy assessment of anti-ICOS-targeting agents in fully immunocompetent mice.

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Application of the genO-hICOS mouse model

Useful applications for researchers working on different biomedical fields, such as immuno-oncology, inflammation and autoimmunity:

  • Assess the efficacy of hICOS-targeting therapeutics
  • Investigate the mode of action (MoA) of hICOS-targeting compounds and understand their therapeutic potential
  • Analyze the biodistribution of hICOS-targeting constructs

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Features

  • Physiological expression of human ICOS
  • Functional T/B cell cooperation
  • Fully functional mouse immune system
  • Lack of expression of the murine target gene

Clients

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Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Validation data

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genO-hICOS

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The genO-hOX40 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint OX40 in fully immunocompetent mice.

CD137
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genO‑hCD137

genO‑hCD137 immunocompetent mice enable the efficacy assessment of anti-CD137.

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Immune checkpoint
CD28
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genO‑hCD28

The genO‑hCD28 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint CD28 in fully immunocompetent mice.

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CD39
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The genO‑hCD39 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint CD39 in fully immunocompetent mice.

Immune checkpoint
GITR
ICP (single-target)

genO‑hGITR

The genO‑hGITR mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR in fully immunocompetent mice.

PD-1
Immune checkpoint
ICP (single-target)

genO‑hPD‑1

The genO‑hPD‑1 mouse enables the in vivo efficacy assessment and profiling of compounds targeting the human immune checkpoint PD-1 in fully immunocompetent mice

Immune checkpoint
VISTA
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genO‑hVISTA

The genO‑hVISTA mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint VISTA in fully immunocompetent mice.

Preclinical Humanized genO-hICOS Mouse Model

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Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

Generated with biopharma partners and in-house

Innovative technologies

and guaranteed freedom to operate

Easy access to models

Models with certified health status from professional breeders in US and Europe