Tissue-Specific Conditional Knockout Mouse Models


Get supplemental information, a quote, and estimated timeframe to generate your tissue-specific KO mouse line.


A tissue-specific Knockout mouse defines an animal model in which a gene of interest is "floxed" and thus inactivatable in specific cell types in a certain tissue. Other cell types and tissues exhibit an unmodified, functional gene expression.

This gene inactivation is achieved by an additional breeding step with a tissue- or cell type-specific Cre-deleter mouse line. Such models also give access to whole body (constitutive) Knockouts.

Infographic: Tissue-specific Knockout mouse model

Typical applications for tissue-specific Knockout mouse models

For academic research:
  • Study gene function in one specific organ, tissue or cell type
  • Mimic pathologies caused by gene inactivation or deficiency in a given cell type
  • Create a tissue-specific phenotype for multi-function proteins
For bio-pharmaceutical research & development:
  • Validate target genes with cell-specific functions
  • Investigate signaling pathways in certain cell types
  • Safety studies

Strengths and limitations of tissue-specific Knockout mouse models

  • Very flexible: easy switch to study another tissue
  • Large resource of deleter mice (Cre or FLP), enabling an almost infinite combination of tissue-specificities
  • High physiological relevancy of the obtained scientific data from such a model
  • Enables access as well to constitutive Knockout for comparison studies
  • Mouse line creation requires the insertion of exogenous sequences (lox, FRT) that can deregulate transcription and splicing
    → Risk can be greatly minimized by applying in-depth bio-informatic, genetic, and bibliographic analysis
  • Inactivation of the gene of interest in one cell type may occur during cell type differentiation, resulting in an impaired phenotype and/or modified cell physiology
    →  Limitation can be bypassed by applying conditions such as time-specific gene inactivation
  • To obtain tissue specificity, a crossing step with a deleter mouse line implies a time-consuming production of cohorts
    →  This "time" issue must be anticipated and integrated in the scientific consulting prior to model development

Case studies and publications on our tissue-specific Knockout mouse models

Case studies


Model for Crohn’s disease (CD)

Tschurtschenthaler M, et al. Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis. J Exp Med. 2017.

ATG16L1T300A, a major risk polymorphism in CD, causes impaired autophagy, but it has remained unclear how this predisposes to CD.

Model: Mice that lack Atg16l1 in intestinal epithelial cells (IECs) (Atg16l1ΔIEC) phenocopying ileal CD observed in humans homozygous for ATG16L1T300A.

Aim: Investigation of the mechanisms engaged by impaired ATG16L1-dependent autophagy that drive ileal inflammation.

Results: Defective autophagy in IECs predispose to CD ileitis via impaired clearance of endoplasmic reticulum (ER) stress sensor IRE1α aggregates during ER stress.
IRE1α accumulates in Paneth cells, specialized IECs, of Atg16l1ΔIEC mice, and humans homozygous for ATG16L1T300A exhibit a corresponding increase of IRE1α in intestinal epithelial crypts.

Figure 1. 35-week-old Atg16l1ΔIEC mice exhibit increased ER stress and transmural CD-like ileitis.

Figure 1 - Atg16l1ΔIEC miceA-B) Representative H&E images (B) and enteritis histology score (C) of 35-week-old Atg16l1ΔIEC mice.

Figure 2. IRE1α expression is increased in 35-week-old Atg16l1ΔIEC mice and ATG16L1T300A patients and drives CD-like ileitis.

Figure 2a - Atg16l1ΔIEC miceA) Representative confocal images of IRE1α immunoreactivity (green; white arrows) in 10- and 35-week-old Atg16l1ΔIEC mice.
Figure 2b - Atg16l1ΔIEC miceB) Representative IRE1α immunoreactivity (green) stratified by the ATG16L1 risk allele (AA/AG/GG; A, healthy allele; G risk allele) in healthy controls (n = 9/22/12) and noninflamed mucosa (n = 9/15/7) of CD patients.

C) Quantification of IRE1α+ crypts shown in B in healthy controls (n = 9/22/12) and CD patients (n = 9/15/7) according to their ATG16L1 genotype (n = 18/37/19).



Tissue: VP-expressing cells
Sevasti Gaspari, Gwenaël Labouèbe, Alexandre Picard, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Bernard Thorens.
Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia.
EMBO Rep. 2023 Jun 14

Tissue: adipocytes
Kacey J Prentice, Alexandra Lee, Paulina Cedillo, Karen E Inouye, Meric Erikci Ertunc, Jillian K Riveros, Grace Yankun Lee, Gökhan S Hotamisligil.
Sympathetic tone dictates the impact of lipolysis on FABP4 secretion.
J Lipid Res. 2023 Jun

Tissue: podocytes
Julia Reichelt, Wiebke Sachs, Sarah Frömbling, Julia Fehlert, Maja Studencka-Turski, Anna Betz, Desiree Loreth, Lukas Blume, Susanne Witt, Sandra Pohl, Johannes Brand, Maire Czesla, Jan Knop, Bogdan I Florea, Stephanie Zielinski, Marlies Sachs, Elion Hoxha, Irm Hermans-Borgmeyer, Gunther Zahner, Thorsten Wiech, Elke Krüger, Catherine Meyer-Schwesinger.
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis.
Nat Commun. 2023 Apr 13

Tissue: whole body
Matthew P Harris, Shemin Zeng, Zhiyong Zhu, Vitor A Lira, Liping Yu, Denice M Hodgson-Zingman, Leonid V Zingman.
Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning.
Int J Mol Sci. 2023 Mar 30

Tissue: whole body
Flora Crozet, Gaëlle Letort, Rose Bulteau, Christelle Da Silva, Adrien Eichmuller, Anna Francesca Tortorelli, Joséphine Blévinal, Morgane Belle, Julien Dumont, Tristan Piolot, Aurélien Dauphin, Fanny Coulpier, Alain Chédotal, Jean-Léon Maître, Marie-Hélène Verlhac, Hugh J Clarke, Marie-Emilie Terret.
Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes.
Life Sci Alliance. 2023 Mar 21

Tissue: whole body
Maja L Nybo, Jone M Kvam, John E Nielsen, Hanne Frederiksen, Katja Spiess, Kristian H R Jensen, Sarina Gadgaard, Anna L S Walser, Jesper S Thomsen, Pamela Cowin, Anders Juul, Martin Blomberg Jensen, Mette M Rosenkilde.
Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.
FASEB J. 2023 Feb

Tissue: intestinal stem cells
Jina Yun, Simon Hansen, Otto Morris, David T Madden, Clare Peters Libeu, Arjun J Kumar, Cameron Wehrfritz, Aaron H Nile, Yingnan Zhang, Lijuan Zhou, Yuxin Liang, Zora Modrusan, Michelle B Chen, Christopher C Overall, David Garfield, Judith Campisi, Birgit Schilling, Rami N Hannoush, Heinrich Jasper.
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
Nat Commun. 2023 Jan 11

Tissue: myeloid and liver-specific cells
Chutima Jansakun, Warangkana Chunglok, Sandro Altamura, Martina Muckenthaler, Simone Staffer, Sabine Tuma-Kellner, Uta Merle, Walee Chamulitrat.
Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH.
JBiochim Biophys Acta Mol Basis Dis. 2023 Jan 1


Tissue: AgRP neurons
Anastasiya Strembitska, Gwenaël Labouèbe, Alexandre Picard, Xavier P Berney, David Tarussio, Maxime Jan, Bernard Thorens.
Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and GCG secretion.
Nat Commun. 2022 Sep 30

Tissue: whole body
Marco Piroth, Daniel J Gorski, Christian Hundhausen, Anne Petz, Simone Gorressen, Dominik Semmler, Heba Zabri, Sonja Hartwig, Stefan Lehr, Malte Kelm, Christian Jung, Jens W Fischer.
Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
Matrix Biol. 2022 Sep

Tissue: airway epithelial cells
Kris Genelyn Dimasuay, Niccolette Schaunaman, Bruce Berg, Diana Cervantes, Elke Kruger, Frank L Heppner, Deborah A Ferrington, Hong Wei Chu.
Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection.
Sci Rep. 2022 Aug 25

Tissue: whole body
Claudia S Bauer, Rebecca N Cohen, Francesca Sironi, Matthew R Livesey, Thomas H Gillingwater, J Robin Highley, Daniel J Fillingham, Ian Coldicott, Emma F Smith, Yolanda B Gibson, Christopher P Webster, Andrew J Grierson, Caterina Bendotti, Kurt J De Vos.
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD.
Acta Neuropathol. 2022 Jul 25

Tissue: whole body
Yinmao Chi, Xiuli Zhang, Dan Liang, Yue Wang, Xiaoyi Cai, Jiqiu Dong, Lingzhi Li, Zhihong Chi.
TZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways
Biol Trace Elem Res. 2022 Jul 23

Tissue: whole body
Ann Hanna, Mellissa J Nixon, M Valeria Estrada, Violeta Sanchez, Quanhu Sheng, Susan R Opalenik, Abigail L Toren, Joshua Bauer, Phillip Owens, Frank M Mason, Rebecca S Cook, Melinda E Sanders, Carlos L Arteaga, Justin M Balko.
Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer
Breast Cancer Res. 2022 Jul 18

Tissue: whole body
S Bullich, P de Souto Barreto, A Dortignac, L He, C Dray, P Valet, B P Guiard.
Apelin controls emotional behavior in age- and metabolic state-dependent manner.
Psychoneuroendocrinology. 2022 Jun

Tissue: CD4+ and CD8+ T lymphocytes
C Macchi, A Moregola, M F Greco, M Svecla, F Bonacina, S Dhup, R K Dadhich, M Audano, P Sonveaux, C Mauro, N Mitro, M Ruscica, G D Norata.
Monocarboxylate transporter 1 deficiency impacts CD8+ T lymphocytes proliferation and recruitment to adipose tissue during obesity.
iScience. 2022 May 23

Tissue: dendritic cells
Andrea Vogel, Katharina Martin, Klara Soukup, Angela Halfmann, Martina Kerndl, Julia S Brunner, Melanie Hofmann, Laura Oberbichler, Ana Korosec, Mario Kuttke, Hannes Datler, Markus Kieler, Laszlo Musiejovsky, Alexander Dohnal, Omar Sharif, Gernot Schabbauer.
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction
Cell Rep. 2022 Feb 22

Tissue: whole body
Gonzalo Garcia-Martin, Miriam Sanz-Rodriguez, Berta Alcover-Sanchez, Marta P Pereira, Francisco Wandosell, Beatriz Cubelos.
R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System
Int J Mol Sci. 2022 Jan 17


Tissue: whole body
Bernard Lassègue, Sandeep Kumar, Rohan Mandavilli, Keke Wang, Michelle Tsai, Dong-Won Kang, Catherine Demos, Marina S Hernandes, Alejandra San Martín, W Robert Taylor, Hanjoong Jo, Kathy K Griendling.
Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting
PLoS One. 2021 Dec 20

Tissue: whole body
Beatrice Romier, Cédric Dray, Laetitia Vanalderwiert, Amandine Wahart, Thinhinane Hocine, Alizée Dortignac, Christian Garbar, Corinne Garbar, Camille Boulagnon, Nicole Bouland, Pascal Maurice, Amar Bennasroune, Hervé Sartelet, Laurent Martiny, Laurent Duca, Philippe Valet, Sébastien Blaise.
Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall.
Sci Rep. 2021 Nov 15

Tissue: whole body
Claire Pujol, Anne Legrand, Livia Parodi, Priscilla Thomas, Fanny Mochel, Dario Saracino, Giulia Coarelli, Marijana Croon, Milica Popovic, Manon Valet, Nicolas Villain, Shahira Elshafie, Mahmoud Issa, Stephane Zuily, Mathilde Renaud, Cécilia Marelli-Tosi, Marine Legendre, Aurélien Trimouille, Isabelle Kemlin, Sophie Mathieu, Joseph G Gleeson, Foudil Lamari, Daniele Galatolo, Rana Alkouri, Chantal Tse, Diana Rodriguez, Claire Ewenczyk, Florence Fellmann, Thierry Kuntzer, Emilie Blond, Khalid H El Hachimi, Frédéric Darios, Alexandre Seyer, Anastasia D Gazi, Patrick Giavalisco, Silvina Perin, Jean-Luc Boucher, Laurent Le Corre, Filippo M Santorelli, Cyril Goizet, Maha S Zaki, Serge Picaud, Arnaud Mourier, Sophie Marie Steculorum, Cyril Mignot, Alexandra Durr, Aleksandra Trifunovic, Giovanni Stevanin.
Implication of folate deficiency in CYP2U1 loss of function.
J Exp Med. 2021 Nov 1

Tissue: epidermal progenitors
Ling Liu, Cristina Rodriguez-Mateo, Polly Huang, Albin Huang, Alexander Lieu, Michelle Mao, Mingyu Chung, Sharon Yang, Kevin Yu, Gregory W Charville, Qiang Gan, Thomas A Rando.
Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist.
Proc Natl Acad Sci U S A. 2021 Sep 14

Tissue: nociceptive sensory neurons
Nguyen Huu Tu, Kenji Inoue, Elyssa Chen, Bethany M Anderson, Caroline M Sawicki, Nicole N Scheff, Hung D Tran, Dong H Kim, Robel G Alemu, Lei Yang, John C Dolan, Cheng Z Liu, Malvin N Janal, Rocco Latorre, Dane D Jensen, Nigel W Bunnett, Laura E Edgington-Mitchell, Brian L Schmidt.
Cathepsin S Evokes PAR 2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models.
Cancers (Basel). 2021 Sep 19

Tissue: myeloid cells
Tina Schreiber, Maren Falk-Paulsen, Jan Kuiper, Konrad Aden, Rainer Noth, Nicolas Gisch, Stefan Schreiber, Philip Rosenstiel, Burkhard Bewig.
IL23R on myeloid cells is involved in murine pulmonary granuloma formation.
Exp Lung Res. 2021 Aug 18

Tissue: cardiac
Marwa Mahmoud, Ian Evans, Laura Wisniewski, Yuen Tam, Claire Walsh, Simon Walker-Samuel, Paul Frankel, Peter Scambler, Ian Zachary.
Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.
Cardiovasc Res. 2021 Jul 16

Tissue: whole body
Alex Lipovsky, Peter F Slivka, Zhi Su, Yibing Wang, Stephanie Paulsboe, Joseph Wetter, Marian T Namovic, Donna Gauvin, Denise Perron, Stephen B Gauld, Steven McGaraughty, Eric R Goedken.
ACT1 Is Required for Murine IL-23-Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity.
J Invest Dermatol. 2021 Jul

Tissue: CD4+ cells
Peter Lehmkuhl, Magdalena Gentz, Andres Caballero Garcia de Otezya, Bodo Grimbacher, Hendrik Schulze-Koops, Alla Skapenko.
Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32.
Cell Mol Immunol. 2021 Jul

Tissue: adipose
Olivia Sveidahl Johansen, Tao Ma, Jakob Bondo Hansen, Lasse Kruse Markussen, Renate Schreiber, Laia Reverte-Salisa, Hua Dong, Dan Ploug Christensen, Wenfei Sun, Thorsten Gnad, Iuliia Karavaeva, Thomas Svava Nielsen, Sander Kooijman, Cheryl Cero, Oksana Dmytriyeva, Yachen Shen, Maria Razzoli, Shannon L O'Brien, Eline N Kuipers, Carsten Haagen Nielsen, William Orchard, Nienke Willemsen, Naja Zenius Jespersen, Morten Lundh, Elahu Gosney Sustarsic, Cecilie Mørch Hallgren, Mikkel Frost, Seth McGonigle, Marie Sophie Isidor, Christa Broholm, Oluf Pedersen, Jacob Bo Hansen, Niels Grarup, Torben Hansen, Andreas Kjær, James G Granneman, M Madan Babu, Davide Calebiro, Søren Nielsen, Mikael Rydén, Raymond Soccio , Patrick C N Rensen, Jonas Thue Treebak, Thue Walter Schwartz, Brice Emanuelli, Alessandro Bartolomucci, Alexander Pfeifer, Rudolf Zechner, Camilla Scheele, Susanne Mandrup, Zachary Gerhart-Hines.
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Cell. 2021 Jun 24

Tissue: kidney tubules
Harini Ramalingam, Sonu Kashyap, Patricia Cobo-Stark, Andrea Flaten, Chun-Mien Chang, Sachin Hajarnis, Kyaw Zaw Hein, Jorgo Lika, Gina M Warner, Jair M Espindola-Netto, Ashwani Kumar, Mohammed Kanchwala, Chao Xing, Eduardo N Chini, Vishal Patel.
A methionine-Mettl3-N 6-methyladenosine axis promotes polycystic kidney disease.
Cell Metab. 2021 Jun 1

Tissue: liver
Michael Shum, Chitra A Shintre, Thorsten Althoff, Vincent Gutierrez, Mayuko Segawa, Alexandra D Saxberg, Melissa Martinez, Roslin Adamson, Margaret R Young, Belinda Faust, Raffi Gharakhanian, Shi Su, Karthickeyan Chella Krishnan, Kiana Mahdaviani, Michaela Veliova, Dane M Wolf, Jennifer Ngo, Laura Nocito, Linsey Stiles, Jeff Abramson, Aldons J Lusis, Andrea L Hevener, Maria E Zoghbi, Elisabeth P Carpenter, Marc Liesa.
ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity.
Sci Transl Med. 2021 May 19

Tissue: whole body
Rebecca A Helmer, Raul Martinez-Zaguilan, Gurvinder Kaur, Lisa A Smith, Jannette M Dufour, Beverly S Chilton.
Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis.
PLoS One. 2021 May 19

Tissue: whole body
Anthony S Castanza, Sanja Ramirez, Prem P Tripathi, Ray A M Daza, Franck K Kalume, Jan-Marino Ramirez, Robert F Hevner.
AUTS2 Regulates RNA Metabolism and Dentate Gyrus Development in Mice.
Cereb Cortex. 2021 May 19

Tissue: whole body
Lisa Baker, Moses Tar, Adam H Kramer, Guillermo A Villegas, Rabab A Charafeddine, Olga Vafaeva, Parimala Nacharaju, Joel Friedman, Kelvin P Davies, David J Sharp.
Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.
JCI Insight. 2021 May 10

Tissue: whole body
Goutam Chandra, Sen Chandra Sreetama, Davi A G Mázala, Karine Charton, Jack H VanderMeulen, Isabelle Richard, Jyoti K Jaiswal.
Endoplasmic reticulum maintains ion homeostasis required for plasma membrane repair.
J Cell Biol. 2021 May 3

Tissue: whole body
Jieru Deng, Chunni Lu, Chuanxin Liu, Sara Oveissi, W Douglas Fairlie, Erinna F Lee, Pamuk Bilsel, Hamsa Puthalakath, Weisan Chen.
Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope.
FEBS J. 2021 May

Tissue: whole body
Maryam Keshavarz, Diethard Tautz.
The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice.
Proc Natl Acad Sci U S A. 2021 Mar 9

Tissue: whole body
Berta Alcover-Sanchez, Gonzalo Garcia-Martin, Juan Escudero-Ramirez, Carolina Gonzalez-Riano, Paz Lorenzo, Alfredo Gimenez-Cassina1 Laura Formentini, Pedro de la Villa-Polo, Marta P Pereira, Francisco Wandosell, Beatriz Cubelos.
Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model.
Glia. 2021 Mar

Tissue: whole body
Nguyen Huu Tu, Dane D Jensen, Bethany M Anderson, Elyssa Chen, Nestor N Jimenez-Vargas, Nicole N Scheff, Kenji Inoue, Hung D Tran, John C Dolan, Tamaryn A Meek, Morley D Hollenberg, Cheng Z Liu, Stephen J Vanner, Malvin N Janal, Nigel W Bunnett, Laura E Edgington-Mitchell, Brian L Schmidt.
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
J Neurosci. 2021 Jan 6


Tissue: forebrain excitatory neurons
Jing Wang, Gangadhara R Sareddy, Yujiao Lu, Uday P Pratap, Fulei Tang, Karah M Greene, Pornjittra L Meyre, Rajeshwar R Tekmal, Ratna K Vadlamudi, Darrell W Brann.
Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury.
J Neurosci. 2020 Dec 9

Tissue: whole body
Caitlin Schneider, Connie Shen, Angelica A Gopal, Todd Douglas, Benjamin Forestell, Keith D Kauffman, Dakota Rogers, Patricio Artusa, Qian Zhang, Huie Jing, Alexandra F Freeman, Daniel L Barber, Irah L King, Maya Saleh, Paul W Wiseman, Helen C Su, Judith N Mandl.
Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response.
Nat Immunol. 2020 Dec

Tissue: whole body
Natalie K Rynkiewicz, Karen E Anderson, Sabine Suire, Daniel M Collins, Eleftherios Karanasios, Oscar Vadas, Roger Williams, David Oxley, Jonathan Clark, Len R Stephens, Phillip T Hawkins.
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.
Sci Signal. 2020 Nov 3

Tissue: endothelial cells
Huijing Xia, Zhen Li, Thomas E Sharp 3rd, David J Polhemus, Jean Carnal, Karl H Moles, Ya-Xiong Tao, John Elrod, Josef Pfeilschifter, Karl-Friedrich Beck, David J Lefer.
Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury.
J Am Heart Assoc. 2020 Oct 20

Tissue: whole body
Patricia Aparicio-Domingo, Hélène Cannelle, Matthew B Buechler, Sylvain Nguyen, Sandra M Kallert, Stéphanie Favre, Nagham Alouche, Natalie Papazian, Burkhard Ludewig, Tom Cupedo, Daniel D Pinschewer, Shannon J Turley, Sanjiv A Luther.
Fibroblast-derived IL-33 is dispensable for lymph node homeostasis but critical for CD8 T-cell responses to acute and chronic viral infection.
Eur J Immunol. 2020 Jul 22

Tissue: whole body
Xiuli Zhang, Tingwen Guan, Boxuan Yang, Harvest F Gu, Zhihong Chi.
Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease.
Cell Death Dis. 2020 Jul 17

Tissue: beta cells
Eleni Georgiadou, Elizabeth Haythorne, Matthew T Dickerson, Livia Lopez-Noriega, Timothy J Pullen, Gabriela da Silva Xavier, Samuel P X Davis, Aida Martinez-Sanchez, Francesca Semplici, Rosario Rizzuto, James A McGinty, Paul M French, Matthew C Cane, David A Jacobson, Isabelle Leclerc, Guy A Rutter.
The Pore-Forming Subunit MCU of the Mitochondrial Ca 2+ Uniporter Is Required for Normal Glucose-Stimulated Insulin Secretion in Vitro and in Vivo in Mice.
Diabetologia. 2020 Jul.

Tissue: midbrain, hypothalamus, telencephalon
Clement Soleilhavoup, Marco Travaglio, Kieran Patrick, Pedro Garção, Elangovan Boobalan, Youri Adolfs, Ruth V Spriggs, Emma Moles-Garcia, Dalbir Dhiraj, Tony Oosterveen, Sarah L Ferri, Ted Abel, Edward S Brodkin, R Jeroen Pasterkamp, Brian P Brooks, Lia Panman.
Nolz1 Expression Is Required in Dopaminergic Axon Guidance and Striatal Innervation.
Nat Commun. 2020 Jun 19.

Tissue: neurons
Benoit de Pins, Enrica Montalban, Peter Vanhoutte, Albert Giralt, Jean-Antoine Girault.
The Non-Receptor Tyrosine Kinase Pyk2 Modulates Acute Locomotor Effects of Cocaine in D1 Receptor-Expressing Neurons of the Nucleus Accumbens.
Sci Rep. 2020 Apr 20.

Tissue: hematopoietic cells
Chen C, Sun MA, Warzecha C, Bachu M, Dey A, Wu T, Adams PD, Macfarlan T, Love P, Ozato K.
HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis.
Cell Rep. 2020 Feb 18.

Tissue: enteric-associated neurons
Matheis F, Muller PA, Graves CL, Gabanyi I, Kerner ZJ, Costa-Borges D, Ahrends T, Rosenstiel P, Mucida D.
Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss.
Cell. 2020 Jan 9.


Tissue: whole body
Liu Q, Li M, Whiteaker P, Shi FD, Morley BJ, Lukas RJ.
Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
Biomolecules. 2019 Dec 4.

Tissue: whole body
Lipinski S, Pfeuffer S, Arnold P, Treitz C, Aden K, Ebsen H, Falk-Paulsen M, Gisch N, Fazio A, Kuiper J, Luzius A, Billmann-Born S, Schreiber S, Nuñez G, Beer HD, Strowig T, Lamkanfi M, Tholey A, Rosenstiel P.
Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles.
EMBO J. 2019 Oct 15.

Tissue: whole body
Lipinski S, Pfeuffer S, Arnold P, Treitz C, Aden K, Ebsen H, Falk-Paulsen M, Gisch N, Fazio A, Kuiper J, Luzius A, Billmann-Born S, Schreiber S, Nuñez G, Beer HD, Strowig T, Lamkanfi M, Tholey A, Rosenstiel P.
Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles.
EMBO J. 2019 Oct 15.

Tissue: whole body
Helmer RA, Kaur G, Smith LA, Chilton BS.
Helicase-like transcription factor (Hltf) gene-deletion promotes oxidative phosphorylation (OXPHOS) in colorectal tumors of AOM/DSS-treated mice.
PLoS One. 2019 Aug 28.

Tissue: whole body
Paggio A, Checchetto V, Campo A, Menabò R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D.
Identification of an ATP-sensitive potassium channel in mitochondria.
Nature. 2019 Aug.

Tissue: macrophages
Rothweiler S, Feldbrügge L, Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC.
Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.
Purinergic Signal. 2019 Jun 26.

Tissue: hepatocytes
Dierickx P, Emmett MJ, Jiang C, Uehara K, Liu M, Adlanmerini M, Lazar MA.
SR9009 has REV-ERB-independent effects on cell proliferation and metabolism.
Proc Natl Acad Sci U S A. 2019 Jun 18.

Tissue: adipocytes
Hurtado Del Pozo C, Ruiz HH, Arivazhagan L, Aranda JF, Shim C, Daya P, Derk J, MacLean M, He M, Frye L, Friedline RH, Noh HL, Kim JK, Friedman RA, Ramasamy R, Schmidt AM.
A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis.
Cell Rep. 2019 Jul 16.

Tissue: whole body
Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW.
4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue.
Nat Metab. 2019 May.

Tissue: whole body
Reinicke AT, Laban K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch PC, Duncan KE5, Saftig P, Rinschen MM, Morellini F, Meyer-Schwesinger C.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Proc Natl Acad Sci U S A. 2019 Apr 16.

Tissue: retina
Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M.
Deubiquitinase USP10 regulates Notch signaling in the endothelium.
Science. 2019 Apr 12.

Tissue: sensory neurons
Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ.
Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.
Cell Rep. 2019 Mar 26.

Tissue: sertoli and granulosa cell, male germ cells
Huang K, Ru B, Zhang Y, Chan WL, Chow SC, Zhang J, Lo C, Lui WY.
Sertoli cell-specific coxsackievirus and adenovirus receptor knockout regulates cell adhesion and gene transcription via β-catenin inactivation and Cdc42 activation.
FASEB J. 2019 Mar 20.

Tissue: whole body
Svärd J, Røst TH, Sommervoll CEN, Haugen C, Gudbrandsen OA, Mellgren AE, Rødahl E, Fernø J, Dankel SN, Sagen JV, Mellgren G.
Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice.
Sci Rep. 2019 Mar 15.

Tissue: whole body
Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck KF, Frank S.
Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.
Nitric Oxide. 2019 Mar 9.

Tissue: Treg lineage
Anandagoda N, Willis JC, Hertweck A, Roberts LB, Jackson I, Gökmen MR, Jenner RG, Howard JK, Lord GM.
microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance.
J Clin Invest. 2019 Feb 11.

Tissue: liver, endothelial cells
Adebayo Michael AO, Ko S, Tao J, Moghe A, Yang H, Xu M, Russell JO, Pradhan-Sundd T, Liu S, Singh S, Poddar M, Monga JS, Liu P, Oertel M, Ranganathan S, Singhi A, Rebouissou S, Zucman-Rossi J, Ribback S, Calvisi D, Qvartskhava N, Görg B, Häussinger D, Chen X, Monga SP.
Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations.
Cell Metab. 2019 Jan 28.

Tissue: whole body
Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, Zhang S, Dong M, Stenmark P, Krupp J.
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Sci Adv. 2019 Jan 16.


Tissue: whole body
Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M.
Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Elife. 2018 Dec 18.

Tissue: cardiac
Unudurthi SD, Nassal D, Greer-Short A, Patel N, Howard T, Xu X, Onal B, Satroplus T, Hong D, Lane C, Dalic A, Koenig SN, Lehnig AC, Baer LA, Musa H, Stanford KI, Smith S, Mohler PJ, Hund TJ.
βIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload.
J Clin Invest. 2018 Dec 3.

Tissue: melanocytes
Zhou D, Ota K, Nardin C, Feldman M, Widman A, Wind O, Simon A, Reilly M, Levin LR, Buck J, Wakamatsu K, Ito S, Zippin JH.
Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH.
Sci Signal. 2018 Nov 6.

Tissue: myeloid cells
Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR.
Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.
Mucosal Immunol. 2018 Oct 18.

Tissue: pancreatic acinar cells
Wolters-Eisfeld G, Mercanoglu B, Hofmann BT, Wolpers T, Schnabel C, Harder S, Steffen P, Bachmann K, Steglich B, Schrader J, Gagliani N, Schlüter H, Güngör C, Izbicki JR, Wagener C, Bockhorn M.
Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice.
Exp Mol Med. 2018 Oct 10.

Tissue: whole body
Böing M, Brand-Saberi B, Napirei M.
Murine transcription factor Math6 is a regulator of placenta development.
Sci Rep. 2018 Oct 9.

Tissue: melanocytes
Webster JD, Pham TH, Wu X, Hughes NW, Li Z, Totpal K, Lee HJ, Calses PC, Chaurushiya MS, Stawiski EW, Modrusan Z, Chang MT, Tran C, Lee WP, Chalasani S, Hung J, Sharma N, Chan S, Hotzel K, Talevich E, Shain A, Xu M, Lill J, Dixit VM, Bastian BC, Dey A.
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
Pigment Cell Melanoma Res. 2018 Aug 29.

Tissue: whole body
Manil-Ségalen M, Łuksza M, Kanaan J, Marthiens V, Lane SIR, Jones KT, Terret ME, Basto R, Verlhac MH.
Chromosome structural anomalies due to aberrant spindle forces exerted at gene editing sites in meiosis.
J Cell Biol. 2018 Aug 6.

Tissue: peripheral neurons
Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Proc Natl Acad Sci U S A. 2018 Jul 31.

Tissue: whole body
Kaur G, Helmer RA, Smith LA, Martinez-Zaguilan R, Dufour JM, Chilton BS.
Alternative splicing of helicase-like transcription factor (Hltf): Intron retention-dependent activation of immune tolerance at the feto-maternal interface.
PLoS One. 2018 Jul 5.

Tissue: adipose
Sustarsic EG, Ma T, Lynes MD, Larsen M, Karavaeva I, Havelund JF, Nielsen CH, Jedrychowski MP, Moreno-Torres M, Lundh M, Plucinska K, Jespersen NZ, Grevengoed TJ, Kramar B, Peics J, Hansen JB, Shamsi F, Forss I, Neess D, Keipert S, Wang J, Stohlmann K, Brandslund I, Christensen C, Jørgensen ME, Linneberg A, Pedersen O, Kiebish MA, Qvortrup K, Han X, Pedersen BK, Jastroch M, Mandrup S, Kjær A, Gygi SP, Hansen T, Gillum MP, Grarup N, Emanuelli B, Nielsen S, Scheele C, Tseng YH, Færgeman NJ, Gerhart-Hines Z.
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.
Cell Metab. 2018 Jul 3.

Tissue: whole body
Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL, Chan LF.
MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.
FASEB J. 2018 Jun 7.

Tissue: whole body
Millership SJ, da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ.
Neuronatin regulates pancreatic β cell INS content and secretion.
J Clin Invest. 2018 Jun 4.

Tissue: whole body
Sanz-Rodriguez M, Gruart A, Escudero-Ramirez J, de Castro F, Delgado-García JM, Wandosell F, Cubelos B.
R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System.
J Neurosci. 2018 May 30.

Tissue: whole body
Mendoza P, Martínez-Martín N, Bovolenta ER, Reyes-Garau D, Hernansanz-Agustín P, Delgado P, Diaz-Muñoz MD, Oeste CL, Fernández-Pisonero I, Castellano E, Martínez-Ruiz A, Alonso-Lopez D, Santos E, Bustelo XR, Kurosaki T, Alarcón B.
R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.
Sci Signal. 2018 May 29.

Tissue: whole body
Schroer AB, Gross JD, Kaski SW, Wix K, Siderovski DP, Vandenbeuch A, Setola V.
Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21).
Chem Senses. 2018 May 23.

Tissue: lymphoid system
Pascall JC, Webb LMC, Eskelinen EL, Innocentin S, Attaf-Bouabdallah N, Butcher GW.
GIMAP6 is required for T cell maintenance and efficient autophagy in mice.
PLoS One. 2018 May 2.

Tissue: whole body
Yassin M, Kissow H, Vainer B, Joseph PD, Hay-Schmidt A, Olsen J, Pedersen AE.
Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice.
Sci Rep. 2018 May 2.

Tissue: whole body
Gallo-Ebert C, Francisco J, Liu HY, Draper R, Modi K, Hayward MD, Jones BK, Buiakova O, McDonough V, Nickels JT Jr.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
J Biol Chem. 2018 Apr 20.


Tissue: CRH neurons
Melón LC, Hooper A, Yang X, Moss SJ, Maguire J.
Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.
Psychoneuroendocrinology. 2017 Dec 20.

Tissue: whole body
Homann S, Grandoch M, Kiene LS, Podsvyadek Y, Feldmann K, Rabausch B, Nagy N, Lehr S, Kretschmer I, Oberhuber A, Bollyky P, Fischer JW.
Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression.
Matrix Biol. 2017 Oct 5.

Tissue: whole body
Little R, Zi M, Hammad SK, Nguyen L, Njegic A, Kurusamy S, Prehar S, Armesilla AL, Neyses L, Austin C, Cartwright EJ.
Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries.
Aging Cell. 2017 Oct.

Tissue: whole body
Liu Q, Whiteaker P, Morley BJ, Shi FD, Lukas RJ.
Distinctive Roles for α7*- and α9*-Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.
Front Cell Neurosci. 2017 Sep 22.

Tissue: whole body
Morley BJ, Dolan DF, Ohlemiller KK, Simmons DD.
Generation and Characterization of α9 and α10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background.
Front Neurosci. 2017 Sep 21.

Tissue: endothelial cells
Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E, Tinker A.
Molecular and functional characterization of the endothelial ATP-sensitive potassium channel.
J Biol Chem. 2017 Sep 11.

Tissue: whole body
Moen LV, Sener Z, Volchenkov R, Svarstad AC, Eriksen AM, Holen HL, Skålhegg BS.
Ablation of the Cβ2 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice.
Eur J Immunol. 2017 Aug 24.

Tissue: whole body
Alsøe L, Sarno A, Carracedo S, Domanska D, Dingler F, Lirussi L, SenGupta T, Tekin NB, Jobert L, Alexandrov LB, Galashevskaya A, Rada C, Sandve GK, Rognes T, Krokan HE, Nilsen H.
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Sci Rep. 2017 Aug 3.

Tissue: myeloid cells, platelets
Beckers CML, Simpson KR, Griffin KJ, Brown JM, Cheah LT, Smith KA, Vacher J, Cordell PA, Kearney MT, Grant PJ, Pease RJ.
Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.
Arterioscler Thromb Vasc Biol. 2017 Aug.

Tissue: whole body
Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Díaz C, de Pins B, Coura R, Alberch J, Ginés S, Poncer JC, Girault JA.
Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.
Nat Commun. 2017 May 30.

Tissue: dentate gyrus hilar neurons
Haidar M, Guèvremont G, Zhang C, Bathgate RAD, Timofeeva E, Smith CM, Gundlach AL.
Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.
Hippocampus. 2017 May.

Tissue: whole body
Dominici C, Moreno-Bravo JA, Puiggros SR, Rappeneau Q, Rama N, Vieugue P, Bernet A, Mehlen P, Chédotal A.
Floor-plate-derived netrin-1 is dispensable for commissural axon guidance.
Nature. 2017 Apr 26.

Tissue: macrophages, vascular endothelial cells
Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CX, Sawyer GJ, Zhang X, Mongue-Din H, Richards DA, Brewer AC, Prysyazhna O, Maier LS, Wenzel P, Eaton PJ, Shah AM.
Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell Nox2 on Blood Pressure.
Circulation. 2017 Mar 15.

Tissue: whole body
Brabletz S, Lasierra Losada M, Schmalhofer O, Mitschke J, Krebs A, Brabletz T, Stemmler MP.
Generation and characterization of mice for conditional inactivation of Zeb1.
Genesis. 2017 Feb 8.

Tissue: intestine
Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP8, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A.
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
J Exp Med. 2017 Feb.

Zhang H, Zheng L, McGovern DP, Hamill AM, Ichikawa R, Kanazawa Y, Luu J, Kumagai K, Cilluffo M, Fukata M, Targan SR, Underhill DM, Zhang X, Shih DQ.
Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.
J Immunol. 2017 Jan 27.


Tissue: dendritic cells
Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS.
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.
J Exp Med. 2016 Sep 19.

Tissue: whole body
Borowiec AS, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, Bokhobza A, Derouiche S, Dewailly E, Slomianny C, Mauduit C, Benahmed M, Roudbaraki M, Jégou B, Prevarskaya N, Bidaux G.
Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.
FASEB J. 2016 Sep.

Tissue: intestine
Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, Häsler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna JL, Kempster SL, Blumberg RS, Schreiber S, Becher B, Chamaillard M, Kaser A4, Rosenstiel P.
Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.
Cell Rep. 2016 Aug 23.

Tissue: liver
Lima WF, Murray HM, Damle SS, Hart CE, Hung G, De Hoyos CL, Liang XH, Crooke ST.
Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function.
Nucleic Acids Res. 2016 Jun 20.

Tissue: pancreatic beta cells
Mehta ZB, Fine N, Pullen TJ, Cane MC, Hu M, Chabosseau P, Meur G, Velayos-Baeza A, Monaco AP, Marselli L, Marchetti P, Rutter GA.
Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.
Am J Physiol Endocrinol Metab. 2016 Aug 1.

Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E.
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Atherosclerosis. 2016 Aug.

Tissue: pancreatic beta cells
Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp JL, Kritzik M, Sicklick JK, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek MA, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T.
Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.
Nature. 2016 Jun 6.

Tissue: neural stem cells
Degrauwe N, Schlumpf TB, Janiszewska M, Martin P, Cauderay A, Provero P, Riggi N, Suvà ML, Paro R, Stamenkovic I.
The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.
Cell Rep. 2016 May 24.

Tissue: whole body
Newton K, Dugger DL, Maltzman A, Greve JM, Hedehus M, Martin-McNulty B, Carano RA, Cao TC, van Bruggen N, Bernstein L, Lee WP, Wu X, DeVoss J, Zhang J, Jeet S, Peng I, McKenzie BS, Roose-Girma M, Caplazi P, Diehl L, Webster JD, Vucic D.
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.
Cell Death Differ. 2016 May 13.

Tissue: whole body
Kim D, Kim YG, Seo SU, Kim DJ, Kamada N, Prescott D, Philpott DJ, Rosenstiel P, Inohara N, Núñez G.
Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin.
Nat Med. 2016 Apr 11.

Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E.
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
J Clin Invest. 2016 Apr 1.

Tissue: whole body
Giralt A, Coura R, Girault JA.
Pyk2 is essential for astrocytes mobility following brain lesion.
Glia. 2016 Apr 1.

Tissue: whole body
Jiang W, St-Pierre S, Roy P, Morley BJ, Hao J, Simard AR.
Infiltration of CCR2+Ly6Chigh Proinflammatory Monocytes and Neutrophils into the Central Nervous System Is Modulated by Nicotinic Acetylcholine Receptors in a Model of Multiple Sclerosis.
J Immunol. 2016 Mar 1.

Tissue: whole body
St-Pierre S, Jiang W, Roy P, Champigny C, LeBlanc É, Morley BJ, Hao J, Simard AR.
Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival.
PLoS One. 2016 Feb 29.

Tissue: whole body
Kiene LS, Homann S, Suvorava T, Rabausch B, Müller J, Kojda G, Kretschmer I, Twarock S, Dai G, Deenen R, Hartwig S, Lehr S1, Köhrer K, Savani RC, Grandoch M, Fischer JW.
Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.
Arterioscler Thromb Vasc Biol. 2016 Feb.


Tissue: whole body
Subbotina E, Sierra A, Zhu Z, Gao Z, Koganti SR, Reyes S, Stepniak E, Walsh SA, Acevedo MR, Perez-Terzic CM, Hodgson-Zingman DM, Zingman LV.
Musclin is an activity-stimulated myokine that enhances physical endurance.
Proc Natl Acad Sci U S A. 2015 Dec 29.

Tissue: endothelial cells
Frye M, Dierkes M, Küppers V, Vockel M, Tomm J, Zeuschner D, Rossaint J, Zarbock A, Koh GY, Peters K, Nottebaum AF, Vestweber D.
Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.
J Exp Med. 2015 Dec 14.

Tissue: whole body
Sánchez-Gómez FJ, Calvo E, Bretón-Romero R, Fierro-Fernández M, Anilkumar N, Shah AM, Schröder K, Brandes RP, Vázquez J, Lamas S.
NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation.
Free Radic Biol Med. 2015 Dec.

Tissue: pancreatic beta cells
Mitchell RK, Hu M, Chabosseau PL, Cane MC, Meur G, Bellomo EA, Carzaniga R, Collinson LM, Li WH, Hodson DJ, Rutter GA.
Molecular genetic regulation of Slc30a8/ZnT8 reveals a positive association with glucose tolerance.
Mol Endocrinol. 2015 Nov 19.

Tissue: platelets
Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW.
The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis.
J Clin Invest. 2015 Nov 3.

Tissue: nociceptive sensory neurons
Syhr KM, Boosen M, Hohmann SW, Longen S, Köhler Y, Pfeilschifter J, Beck KF, Geisslinger G, Schmidtko A, Kallenborn-Gerhardt W.
The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.
Brain Res. 2015 Oct 22.

Tissue: whole body
Alvarez S, Díaz M, Flach J, Rodriguez-Acebes S, López-Contreras AJ, Martínez D, Cañamero M, Fernández-Capetillo O, Isern J, Passegué E, Méndez J.
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nat Commun. 2015 Oct 12.

Tissue: pancreatic alpha cells
Solomou A, Meur G, Bellomo E, Hodson DJ, Tomas A, Migrenne Li S, Philippe E, Herrera PL, Magnan C, Rutter GA.
The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced GLU Secretion.
J Biol Chem. 2015 Jul 15.

Tissue: endothelial cells
Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA.
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
J Exp Med. 2015 Jun 29.

Tissue: endothelial cells
Dowsett L, Piper S, Slaviero A, Dufton N, Wang Z, Boruc O, Delahaye M, Colman L, Kalk E, Tomlinson J, Birdsey G, Randi AM, Leiper J.
Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis.
Circulation. 2015 Jun 23.

Tissue: whole body
Bidaux G, Borowiec AS, Gordienko D, Beck B, Shapovalov GG, Lemonnier L, Flourakis M, Vandenberghe M, Slomianny C, Dewailly E, Delcourt P, Desruelles E, Ritaine A, Polakowska R, Lesage J, Chami M, Skryma R, Prevarskaya N.
Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner.
Proc Natl Acad Sci U S A. 2015 Jun 15.

Tissue: whole body
Kramer NJ, Wang WL, Reyes EY, Kumar B, Chen CC, Ramakrishna C, Cantin EM, Vonderfecht SL, Taganov KD, Chau N, Boldin MP.
Altered lymphopoiesis and immunodeficiency in miR-142 null mice.
Blood. 2015 Jun 11.

Tissue: whole body
Mellgren AE, Bruland O, Vedeler A, Saraste J, Schönheit J, Bredrup C, Knappskog PM, Rødahl E.
Development of congenital stromal corneal dystrophy is dependent on export and extracellular deposition of truncated decorin.
Invest Ophthalmol Vis Sci. 2015 May 31.

Tissue: liver
Qvartskhava N, Lang PA, Görg B, Pozdeev VI, Ortiz MP, Lang KS, Bidmon HJ, Lang E, Leibrock CB, Herebian D, Bode JG, Lang F, Häussinger D.
Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase.
Proc Natl Acad Sci U S A. 2015 Apr 28.

Tissue: whole body
Barneo-Muñoz M, Juárez P, Civera-Tregón A, Yndriago L, Pla-Martin D, Zenker J, Cuevas-Martín C, Estela A, Sánchez-Aragó M, Forteza-Vila J, Cuezva JM, Chrast R, Palau F.
Lack of GDAP1 Induces Neuronal Calcium and Mitochondrial Defects in a Knockout Mouse Model of Charcot-Marie-Tooth Neuropathy.
PLoS Genet. 2015 Apr 10.

Tissue: whole body
Gampe K, Stefani J, Hammer K, Brendel P, Pötzsch A, Enikolopov G, Enjyoji K, Acker-Palmer A, Robson SC, Zimmermann H.
NTPDase2 and purinergic signaling control progenitor cell proliferation in neurogenic niches of the adult mouse brain.
Stem Cells. 2015 Jan 31.

Tissue: endothelial cells
Birdsey GM, Shah AV, Dufton N, Reynolds LE, Osuna Almagro L, Yang Y, Aspalter IM, Khan ST, Mason JC, Dejana E, Göttgens B, Hodivala-Dilke K, Gerhardt H, Adams RH, Randi AM.
The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling.
Dev Cell. 2015 Jan 20.

Tissue: pancreatic beta cells
Patel D, Ythier D, Brozzi F, Eizirik DL, Thorens B.
Clic4, a novel protein that sensitizes β-cells to apoptosis.
Mol Metab. 2015 Jan 12.


Tissue: whole body
Shih DQ, Zheng L, Zhang X, Zhang H, Kanazawa Y, Ichikawa R, Wallace KL, Chen J, Pothoulakis C, Koon HW, Targan SR
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis.
Mucosal Immunol. 2014 Nov.

Tissue: whole body
Ilmjärv S, Reimets R, Hundahl CA, Luuk H
Effect of light on global gene expression in the neuroglobin-deficient mouse retina.
Biomed Rep. 2014 Nov.

Tissue: whole body
Smith ML, Oliveira Souza FG, Bruce KS, Strang CE, Morley BJ, Keyser KT
Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse
Molecular Vision. 2014 Sep 20.

Tissue: endothelial cells
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock AS, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL, Ahluwalia A, Hobbs AJ
Endothelial C-type natriuretic peptide maintains vascular homeostasis.
J Clin Invest. 2014 Sep 2.

Tissue: endothelial cells
Daniel JM, Penzkofer D, Teske R, Dutzmann J, Koch A, Bielenberg W, Bonauer A, Boon RA, Fischer A, Bauersachs J, van Rooij E, Dimmeler S, Sedding DG.
Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury.
Cardiovasc Res. 2014 Sep 1.

Tissue: whole body
Nilsen A, Fusser M, Greggains G, Fedorcsak P, Klungland A
ALKBH4 Depletion in Mice Leads to Spermatogenic Defects.
PLoS One. 2014 Aug 25.

Tissue: skin stem cells
Foronda M, Martínez P, Schoeftner S, Gómez-López G, Schneider R, Flores JM, Pisano DG, Blasco MA
Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation.
Cell Rep. 2014 Jul 15.

Tissue: cardiomyocytes, hematopoietic cells
Penzkofer D, Bonauer A, Fischer A, Tups A, Brandes RP, Zeiher AM, Dimmeler S
Phenotypic Characterization of miR-92a-/- Mice Reveals an Important Function of miR-92a in Skeletal Development.
PLoS One. 2014 Jun 30.

Tissue: epithelial, hemophilic, hematopoietic cells, hepatocytes
Fahs SA, Hille MT, Shi Q, Weiler H, Montgomery RR
A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.
Blood. 2014 Jun 12.

Tissue: pancreatic beta cells
Li LC, Wang Y, Carr R, Haddad CS, Li Z, Qian L, Oberholzer J, Maker AV, Wang Q, Prabhakar BS
IG20/MADD Plays a Critical Role in Glucose-Induced INS Secretion.
Diabetes. 2014 May.

Tissue: fibroblasts
Liu S, Thompson K, Leask A.
CCN2 expression by fibroblasts is not required for cutaneous tissue repair.
Wound Repair Regen. 2014 Jan.


Tissue: whole body
Grabrucker S, Proepper C, Mangus K, Eckert M, Chhabra R, Schmeisser MJ, Boeckers TM, Grabrucker AM.
The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation.
Exp Neurol. 2013 Dec 29.

Tissue: interneurons
Lee V, Maguire J.
Impact of inhibitory constraint of interneurons on neuronal excitability.
J Neurophysiol. 2013 Dec.

Tissue: whole body
Helmer RA, Martínez-Zaguilán R, Dertien JS, Fulford C, Foreman O, Peiris V, Chilton BS.
Helicase-like transcription factor (hltf) regulates g2/m transition, wt1/gata4/hif-1a cardiac transcription networks, and collagen biogenesis.
PLoS One. 2013 Nov 20.

Tissue: intestinal epithelium
Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS.
Paneth cells as a site of origin for intestinal inflammation.
Nature. 2013 Nov 14.

Tissue: whole body
Banning A, Regenbrecht CR, Tikkanen R.
Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model.
Cell Signal. 2013 Nov 9.

Tissue: whole body
Crowe J, Aubareda A, McNamee K, Przybycien PM, Lu X, Williams RO, Bou-Gharios G, Saklatvala J, Dean JL.
Heat shock protein b1-deficient mice display impaired wound healing.
PLoS One. 2013 Oct 15.

Tissue: whole body
Vandenbeuch A, Anderson CB, Parnes J, Enjyoji K, Robson SC, Finger TE, Kinnamon SC.
Role of the ectonucleotidase NTPDase2 in taste bud function.
Proc Natl Acad Sci U S A. 2013 Aug 19.

Tissue: platelets
Kim K, Hahm E, Li J, Holbrook LM, Sasikumar P, Stanley RG, Ushio-Fukai M, Gibbins JM, Cho J.
Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice.
Blood. 2013 Aug 8.

Tissue: cardiomyocytes
Hinkel R, Penzkofer D, Zühlke S, Fischer A, Husada W, Xu QF, Baloch E, van Rooij E, Zeiher AM, Kupatt C, Dimmeler S.
Inhibition of MicroRNA-92a Protects Against Ischemia-Reperfusion Injury in a Large Animal Model.
Circulation. 2013 Jul 29.

Tissue: whole body
Helmer RA, Foreman O, Dertien JS, Panchoo M, Bhakta SM, Chilton BS.
Role of helicase-like transcription factor (hltf) in the g2/m transition and apoptosis in brain.
PLoS One. 2013 Jun 24.

Tissue: whole body
Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG.
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
Nat Commun. 2013 May 14.

Tissue: myeloid cells
Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J.
Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation.
Blood. 2013 May 9.

Tissue: whole body
Ehrmann I, Dalgliesh C, Liu Y, Danilenko M, Crosier M, Overman L, Arthur HM, Lindsay S, Clowry GJ, Venables JP, Fort P, Elliott DJ.
The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of Neurexin Pre-mRNAs in the Brain.
PLoS Genet. 2013 Apr 25.

Tissue: whole body
Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J, Wang W, Cockerill G, Mori K, Li JY, Chien S, Hu Y, Xu Q.
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.
Circulation. 2013 Apr 23.

Tissue: whole body
Chen J, Martinez J, Milner TA, Buck J, Levin LR.
Neuronal Expression of Soluble Adenylyl Cyclase in the Mammalian Brain.
Brain Res. 2013 Apr 20.

Tissue: whole body
Solberg A, Robertson AB, Aronsen JM, Rognmo O, Sjaastad I, Wisløff U, Klungland A.
Deletion of mouse Alkbh7 leads to obesity.
J Mol Cell Biol. 2013 Apr 8.

Tissue: whole body
McManaman JL, Bales ES, Orlicky DJ, Jackman M, Maclean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS.
Perilipin-2 Null Mice are Protected Against Diet-Induced Obesity, Adipose Inflammation and Fatty Liver Disease.
J Lipid Res. 2013 Feb 12.

Tissue: whole body
Simard AR, Gan Y, St-Pierre S, Kousari A, Patel V, Whiteaker P, Morley BJ, Lukas RJ, Shi FD.
Differential modulation of EAE by α9*- and β2*-nicotinic acetylcholine receptors.
Immunol Cell Biol. 2013 Feb 12.

Tissue: whole body
Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill G, Hu Y, Xu Q, Zeng L.
XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation.
J Biol Chem. 2013 Jan 11.

Tissue: whole body
Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C.
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Mol Cell. 2013 Jan 10.


Tissue: whole body
Della-Zuana O, Audinot V, Levenez V, Ktorza A, Presse F, Nahon JL, Boutin JA.
Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models.
Front Endocrinol (Lausanne). 2012 Dec 21.

Tissue: whole body
Clement JP, Aceti M, Creson TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller BH, Wiltgen BJ, Miller CA, Xu X, Rumbaugh G.
Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.
Cell. 2012 Nov 9.

Tissue: pancreatic beta cells
da Silva Xavier G, Mondragon A, Sun G, Chen L, McGinty JA, French PM, Rutter GA.
Abnormal glucose tolerance and INS secretion in pancreas-specific Tcf7l2-null mice.
Diabetologia. 2012 Oct

Tissue: whole body
Dey A, Seshasayee D, Noubade R, French DM, Liu J, Chaurushiya MS, Kirkpatrick DS, Pham VC, Lill JR, Bakalarski CE, Wu J, Phu L, Katavolos P, LaFave LM, Abdel-Wahab O, Modrusan Z, Seshagiri S, Dong K, Lin Z, Balazs M, Suriben R, Newton K, Hymowitz S, Garcia-Manero G, Martin F, Levine RL, Dixit VM.
Loss of the tumor suppressor BAP1 causes myeloid transformation.
Science. 2012 Sep 21.

Tissue: whole body
Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S.
Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.
J Pathol. 2012 Sep.

Tissue: whole body
Lutzmann M, Grey C, Traver S, Ganier O, Maya-Mendoza A, Ranisavljevic N, Bernex F, Nishiyama A, Montel N, Gavois E, Forichon L, de Massy B, Méchali M.
MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.
Mol Cell. 2012 Aug 24.

Tissue: whole body
Raida Z, Hundahl CA, Kelsen J, Nyengaard JR, Hay-Schmidt A.
Reduced infarct size in neuroglobin-null mice after experimental stroke in vivo.
Exp Transl Stroke Med. 2012 Aug 20.

Tissue: whole body
Hundahl CA, Fahrenkrug J, Luuk H, Hay-Schmidt A, Hannibal J.
Restricted expression of Neuroglobin in the mouse retina and co-localization with Melanopsin and Tyrosine Hydroxylase.
Biochem Biophys Res Commun. 2012 Aug 17.

Tissue: whole body
Kovacevic I, Hu J, Siehoff-Icking A, Opitz N, Griffin A, Perkins AC, Munn AL, Müller-Esterl W, Popp R, Fleming I, Jungblut B, Hoffmeister M, Oess S.
The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
EMBO J. 2012 Aug 1.

Tissue: whole body
Garanto A, Vicente-Tejedor J, Riera M, de la Villa P, Gonzàlez-Duarte R, Blanco R, Marfany G.
Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer.
Biochim Biophys Acta. 2012 Aug.

Tissue: whole body
Petrova E, López-Gay JM, Rhiner C, Moreno E.
Flower-deficient mice have reduced susceptibility to skin papilloma formation.
Dis Model Mech. 2012 Jul.

Tissue: whole body
Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, Rossier BC, Hummler E.
The glucocorticoid-induced leucine zipper (gilz/tsc22d3-2) gene locus plays a crucial role in male fertility.
Mol Endocrinol. 2012 Jun.

Tissue: whole body
Hartleben B, Widmeier E, Wanner N, Schmidts M, Kim ST, Schneider L, Mayer B, Kerjaschki D, Miner JH, Walz G, Huber TB.
Role of the polarity protein scribble for podocyte differentiation and maintenance.
PLoS One. 2012 May 7.

Tissue: pancreatic beta cells
Hardy AB, Wijesekara N, Genkin I, Prentice KJ, Bhattacharjee A, Kong D, Chimienti F, Wheeler MB.
Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8.
Am J Physiol Endocrinol Metab. 2012 May;302(9):E1084-96. Epub 2012 Feb 14.

Tissue: hepatocytes
Lamacchia C, Rodriguez E, Palmer G, Vesin C, Seemayer CA, Rubbia-Brandt L, Gabay C.
Mice deficient in hepatocyte-specific IL-1Ra show delayed resolution of concanavalin A-induced hepatitis.
Eur J Immunol. 2012 May.

Tissue: whole body
Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck St, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM.
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.
Nature. 2012 Apr 29.

Tissue: whole body
Hundahl CA, Fahrenkrug J, Hay-Schmidt A, Georg B, Faltoft B, Hannibal J.
Circadian behaviour in neuroglobin deficient mice.
PLoS One. 2012 Apr 5.

Tissue: hippocampus
Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y.
EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.
Neuron. 2012 Feb 23.


Tissue: whole body
Hundahl CA, Luuk H, Ilmjärv S, Falktoft B, Raida Z, Vikesaa J, Friis-Hansen L, Hay-Schmidt A.
Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo.
PLoS One. 2011 Dec 2.

Tissue: whole body
Whelan G, Kreidl E, Wutz G, Egner A, Peters JM, Eichele G.
Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin.
EMBO J. 2011 Nov 18.

Tissue: glia cells
Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, Gundersen GA, Skare Ø, Laake P, Klungland A, Thorén AE, Burkhardt JM, Ottersen OP, Nagelhus EA.
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.
Proc Natl Acad Sci U S A. 2011 Oct 25.

Tissue: whole body
Liu S, Leask A.
CCN2 is not required for skin development.
J Cell Commun Signal. 2011 Aug.

Tissue: whole body
Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU.
Glutaminyl Cyclase Knock-out Mice Exhibit Slight Hypothyroidism but No Hypogonadism: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT.
J Biol Chem. 2011 Apr 22.

Tissue: whole body
Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Thrane VR, Enger R, Haj-Yasein NN, Skare O, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA.
Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
Proc Natl Acad Sci U S A. 2011 Jan 11.

Tissue: fibroblasts, smooth muscle cells
Liu S, Shi-wen X, Abraham DJ, Leask A.
CCN2 is required for blm-induced skin fibrosis in mice.
Arthritis Rheum. 2011 Jan.


Tissue: whole body
Jawhar S, Wirths O, Schilling S, Graubner S, Demuth HU, Bayer TA.
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate abeta formation, induces behavioral deficits and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
J Biol Chem. 2010 Dec 10.

Tissue: nociceptive sensory neurons
Holland S, Coste O, Zhang DD, Pierre SC, Geisslinger G, Scholich K.
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1)-internalization through inhibition of p38 MAPK signaling.
J Biol Chem. 2010 Nov 23.

Tissue: whole body
Zhang M, Brewer AC, Schröder K, Santos CX, Grieve DJ, Wang M, Anilkumar N, Yu B, Dong X, Walker SJ, Brandes RP, Shah AM.
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.
Proc Natl Acad Sci U S A. 2010 Oct 19.

Tissue: hepatocytes, myeloid cells
Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C.
Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice.
J Immunol. 2010 Aug 15.

Tissue: pancreatic alpha cells
Wijesekara N, Dai FF, Hardy AB, Giglou PR, Bhattacharjee A, Koshkin V, Chimienti F, Gaisano HY, Rutter GA, Wheeler MB.
Beta cell-specific Znt8 deletion in mice causes marked defects in INS processing, crystallisation and secretion.
Diabetologia. 2010 Aug.

Tissue: keratinocytes
Martinez P, Thanasoula M, Carlos AR, Gómez-López G, Tejera AM, Schoeftner S, Dominguez O, Pisano DG, Tarsounas M, Blasco MA.
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
Nat Cell Biol. 2010 Aug.

Tissue: pancreatic beta cells, neurons
Sun G, Tarasov AI, McGinty J, McDonald A, da Silva Xavier G, Gorman T, Marley A, French PM, Parker H, Gribble F, Reimann F, Prendiville O, Carzaniga R, Viollet B, Leclerc I, Rutter GA.
Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses INS release in vivo.
Diabetologia. 2010 May.

Tissue: endothelial cells
Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K.
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.
Genes Dev. 2010 May.

Tissue: endothelial cells
D'Amico G, Korhonen EA, Waltari M, Saharinen P, Laakkonen P, Alitalo K.
Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report.
Arterioscler Thromb Vasc Biol. 2010 Feb.

Tissue: myeloid cells
Lamacchia C, Palmer G, Seemayer CA, Talabot-Ayer D, Gabay C.
Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloidcell-specific interleukin-1 receptor antagonist.
Arthritis Rheum. 2010 Feb.


Tissue: whole body
Bujakowska K, Maubaret C, Chakarova CF, Tanimoto N, Beck SC, Fahl E, Humphries MM, Kenna PF, Makarov E, Makarova O, Paquet-Durand F, Ekström PA, van Veen T, Leveillard T, Humphries P, Seeliger MW, Bhattacharya SS.
Study of gene-targeted mouse models of splicing factor gene Prpf31 implicated in human autosomal dominant retinitis pigmentosa (RP).
Invest Ophthalmol Vis Sci. 2009 Dec.

Tissue: whole body
Lemaire K, Ravier MA, Schraenen A, Creemers JW, Van de Plas R, Granvik M, Van Lommel L, Waelkens E, Chimienti F, Rutter GA, Gilon P, in't Veld PA, Schuit FC.
INS crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.
Proc Natl Acad Sci U S A. 2009 Sep 1.

Tissue: whole body
Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.
INS storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.
Diabetes. 2009 Sep.

Tissue: whole body
Guyon A, Tardy MP, Rovère C, Nahon JL, Barhanin J, Lesage F.
Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels.
J Neurosci. 2009 Feb 25.

Tissue: epiblasts
MacDonald ST, Bamforth SD, Chen CM, Farthing CR, Franklyn A, Broadbent C, Schneider JE, Saga Y, Lewandoski M, Bhattacharya S.
Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency
Cardiovasc Res. 2008 Aug 1.

Tissue: whole body
Bensoussan V, Lallemand Y, Moreau J, Cloment CS, Langa F, Robert B.
Generation of an Msx2-GFP conditional null allele.
Genesis. 2008 May.

Tissue: whole body
Lastres-Becker I, Brodesser S, Lütjohann D, Azizov M, Buchmann J, Hintermann E, Sandhoff K, Schürmann A, Nowock J, Auburger G.
INS receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
Hum Mol Genet. 2008 Feb 13.

Tissue: whole body
Risebro CA, Smart N, Dupays L, Breckenridge R, Mohun TJ, Riley PR.
Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart.
Development. 2006 Nov.


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