Related resources and publications
Humanized ICP mouse and cell lines
Humanized PD-1/PD-L1 mouse and cell line
Humanized PD-1 & GITR mouse
T-cell engager
Assess toxicity with ICP
Immuno-oncolology models
The humanized STING model, developed by Knockin at the mouse STING locus, expresses a full human STING.
Different versions of hSTING models are available:
STING is entirely humanizedPhysiological regulation of the human STINGFully functional mouse immune systemLack of expression of the murine target gene, thus avoiding cross-reactivityhSTING validation*
Cytokine levels were measured in serum from DMXAA- or GSK-compound-treated mice.
Humanized ICP mouse and cell lines
Humanized PD-1/PD-L1 mouse and cell line
Humanized PD-1 & GITR mouse
T-cell engager
Assess toxicity with ICP
Immuno-oncolology models
The hGITR/Foxp3 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR. The red fluorescent protein regulated under the Foxp3 promoter allows you to efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs.
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