Applications of the genO‑hSTING mouse model

Broad range of applications in the fields of immuno-oncology, immuno-inflammation and autoimmunity:

  • Assess the efficacy of STING-targeting small molecule compounds
    • Perform tumor inhibition assays
    • Test compounds for the inhibition of inflammatory responses
  • Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential

Features

  • Physiological regulation of the human STING
  • Fully functional mouse immune system
  • Lack of expression of the murine target gene
  • Different versions of genO‑hSTING models are available:

Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Discover related products to

genO‑hSTING

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cGAS
cGAS-STING pathway

genO‑hcGAS

The genO‑hcGAS mouse enables the in vivo assessment of agents and therapies targeting the cGAS–STING cytosolic DNA sensing pathway in fully immunocompetent mice.

Preclinical humanized genO‑hSTING mouse model

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Easy access to models

Models with certified health status from professional breeders in US and Europe