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Applications of the genO‑hcGAS/TREX1D18N mouse model
Range of applications in the fields of inflammation and autoimmunity:
- Assess the efficacy of cGAS or TREX1-targeting compounds
- Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits
Features
- Physiological regulation and expression of humanized cGAS
- The D18N mutation in TREX1 leads to the development of lupus-like pathology
- Fully functional mouse immune system
- Lack of expression of the murine target gene
Guide: Compare cGAS/STING mouse models for drug assessment. Read the guide →
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