Mouse model generation

Tailored mouse models for accurate predictions, drawing on our 25 years of experience.

Why use a customized mouse model?

Customized mouse models stand at the forefront of precision research, offering tailor-made solutions to address the specific needs of scientific inquiry.

Leveraging state-of-the-art genetic engineering techniques, these models can be precisely modified to include gene Knockouts, Knockins, point mutations, or conditional alleles, allowing researchers to investigate the function of specific genes or pathways.

With a commitment to flexibility and scientific excellence, we empower researchers with the ability to design and create mouse models that closely mimic human conditions, fostering groundbreaking discoveries across various fields, from basic biology to preclinical drug development. Whether the goal is to study disease mechanisms, assess therapeutic targets, or validate drug candidates, we provide a versatile and reliable platform for advancing scientific understanding and driving innovation.

Our services for

Mouse model generation

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Mouse
Knockin
Permissive locus
Customized

Quick KI mouse

The Rosa26 and Hprt gene loci are well suited for gene over-expression, reduced development time and cost with ready-to-use targeting vectors.

Mouse
Knockin
Reporter
Customized

Reporter KI mouse

Use a reporter mouse Knockin for in vivo monitoring of transcriptional promoter activity, protein localization, cell trafficking, etc.

Mouse
Knockin
Point mutation
Customized

Point mutation KI mouse

Use a point mutation mouse Knockin to circumvent complex phenotypes arising from complete Knockouts (e.g., signaling pathway problems, cross-reactivity).

Mouse
Knockin
Customized

Humanized KI mouse

Use humanized mice as in vivo tools for mimicking human pathological conditions and diseases, and for conducting preclinical research.

Mouse
Knockout
Point mutation
Customized

Protein function KO mouse

A protein function Knockout mouse defines a model in which one or more nucleotides are mutated in a way that the protein loses its function.

Mouse
Knockout
Constitutive
Customized

Constitutive KO mouse

A constitutive, conventional, or whole-body Knockout mouse is a fast and cost-effective solution for in vivo preliminary studies of target gene functions.

Mouse
Knockout
Conditional
Time-dependent
Customized

Time-dependent KO mouse

Use an inducible conditional Knockout mouse to age-dependently inactivate your gene, and to enable studies at defined development stages or on age-related diseases.

Mouse
Knockout
Conditional
Tissue-specific
Customized

Tissue-specific KO mouse

Use tissue- or cell-specific conditional Knockout mouse models to bypass embryonic lethality, compensatory mechanisms, complex phenotypes, etc.

Related ressources et publication
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