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genO‑BRGSF-A2-HIS
Humanized mice (HIS/human immune system)

genO‑BRGSF-A2-HIS mouse model

genO‑BRGSF-A2-HIS mice possess the most functional reconstituted human immune system. HLA molecules on thymic epithelial cells hinder T-cell cross-reactivity.

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Design of the genO‑BRGSF‑A2‑HIS mouse

The genO‑BRGSF‑A2‑HIS model is generated by inserting a human leukocyte antigen serotype A2 (HLA-A2) class I transgene in the genome of genO-BRGSF (Balb/c Rag2tm1Fwa IL2rγtm1Cgn SirpαNOD Flk2tm1Irl) mice. These mice are subsequently used as recipients to reconstitute a functional human immune system (HIS) to create genO‑BRGSF-A2-HIS mouse models.

Applications

The presence of HLA molecules on genO‑BRGSF‑A2‑HIS thymic epithelial cells hinders T cell cross-reactivity, making this model an invaluable tool to study:

  • Human cytotoxic T lymphocyte responses against human infectious diseases and malignancies
  • Preclinical efficacy of immunotherapies
  • Mechanisms regulating the expression of senescence biomarkers

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Features

The genO‑BRGSF‑A2‑HIS mouse model possesses all of the major human hematopoietic cell subsets, such as B cells, T cells (including CD4+ Treg cells), NK cells, and the myeloid compartment including dendritic cells (DCs), plasmacytoid dendritic cells (pDCs) and monocytes/macrophages.

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  • Highly permissive to human xenograft, including primary or established tumor cells (CDX or PDXs) by virtue of the SIRPαNOD allele expression
  • Lifespan after humanization similar to that of the wild-type mouse ⇨ supports long-term engraftment studies
  • Robustness to traveling (stable immune system)
  • Suitable to assess the effects of radiation treatment in vivo due to the absence of the SCID mutation on a BALB/c background
  • A complete, functional complement system makes this a powerful tool for complement-dependent cytotoxicity (CDC) studies
  • A robust model to study T-cell responsiveness to infection- or tumor-associated antigens in the context of the human MHC molecules

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Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Validation data

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genO‑BRGSF-A2-HIS

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BRGSF
Immunodeficient

genO‑BRGSF

The genO-BRGSF mouse is the most immunodeficient model developed so far, relative to strains like NOD-SCID and NSG.

BRGSF
HIS

genO‑BRGSF‑HIS

genO‑BRGSF‑HIS mice possess the most functional reconstituted human immune system currently on the market and are highly relevant for translational research.

genO‑BRGSF-A2-HIS mouse model

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Models with certified health status from professional breeders in US and Europe