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Applications of the genO‑hCD47/hSIRPα/hFcγR mouse model
Useful applications for researchers working in different biomedical fields, such as immuno-oncology, inflammation and autoimmunity:
- Assess the efficacy of CD47- and/or SIRPα-targeting antibodies and understand the contribution of the Fc region:
- Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
- Evaluate the safety and toxicity of compounds
- Rank Fc-engineered antibodies with enhanced or reduced binding to FcγR
- Analyze the biodistribution of CD47- and/or SIRPα-targeting compounds
- Investigate the mode of action (MoA) of CD47- and/or SIRPα-targeting antibodies with or without an engineered Fc region, and understand their therapeutic potential
Features
- Human-like expression pattern of hFcγR
- Expression of different human CD47 and human SIRPα isoforms
- Physiological regulation and expression pattern of the human CD47 and human SIRPα
- Functional Fcγ receptors enabling assessment of Fc-mediated effector functions
- Preservation of the CD47/SIRPα target-ligand interaction
- Fully functional mouse immune system
- Lack of expression of the murine target genes, thus avoiding cross-reactivity
- No expression of murine FcγR
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