Knockout Mouse Models

Knockout mouse models

Knockout by gene deletion

A gene Knockout mouse defines an animal model in which, by means of gene targeting, one or more genes of interest are disrupted or inactivated.

The loss of gene activity often causes changes in the phenotype of the model animal, allowing in vivo studies of gene function and biological mechanisms. They are suited as tools for human diseases, pharmacological studies and drug development.

Basically, two approaches are very common:

Knockout by gene substitution

When studying protein functions or signaling pathways, a gene substitution such as the introduction of a point mutation that causes a loss of function of the protein of interest gives access to a mouse model of higher physiological relevance. Typically, a reporter is introduced at the same time, allowing gene expression monitoring.



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