Customized Mouse Models
Why use a fully customized mouse model?
We at genOway have specialized in the customization of genetically modified mouse models for over 20 years, and strongly believe that it's the way to go in order to access the most adapted, highly physiologically relevant animal models to:
- Heavily impact the scientific value of your studies, as the model is designed to specifically address your scientific questions while avoiding the unrevealed caveats possible in genetically modified models
- Increase the physiological relevancy of the study conducted using the model
- Enable access to a versatile model through anticipation of the next steps of your in vivo study
The outcome is accurate data and flexibility in subsequent investigations and throughout the entire lifespan of your project, thereby saving you on the total cost of your study.
Our customized mouse model services
| Knockout mouse model | |
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Constitutive KO Permanent inactivation of the target gene, and total absence of the protein in the whole animal, in every cell of the organism |
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| Conditional KO | |
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Tissue-specific KO Gene of interest is inactivated in specific cell types in a certain tissue |
Inducible KO Gene of interest can be temporally controlled at a given time-point in embryonic, post-natal or adult animals |
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Functional KO One or more mutated nucleotides causing loss of function of a given protein |
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| Knockin mouse model | |
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Constitutive KI Add a gene sequence of interest to an endogenous locus |
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Quick KI Controlled gene expression by targeting permissive loci Rosa26 or Hprt |
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Point mutation KI One or more constitutively mutated nucleotides affecting the function of a given protein (gain/loss of function) |
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Reporter KI With inserted fluorescent, bioluminescent proteins or biochemical tags |
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Humanization KI Substitute a mouse gene sequence with the human counterpart |
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Learn more about our customized mouse model service:
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Follow this link if you are looking for another transgenic model.