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Applications of the genO‑panhCD3/hCD28 mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology and autoimmunity:
- Assess the efficacy of diverse compounds such as:
- T-cell engagers targeting both hCD3 and hCD137 (4-1BB)
- Therapeutics targeting hCD137 (4-1BB), such as bispecific antibodies and immune checkpoint inhibitors
- Evaluate the safety of T-cell engagers
- Investigate the mode of action (MoA) of hCD137-targeting compounds or T-cell engagers
Features
- Physiological expression of human CD3 and human CD137
- Expression of different hCD137 isoforms
- Functional CD3/TCR interaction
- Functional T/B cell cooperation
- Fully functional, and with unchanged homeostasis, mouse immune system
- Lack of expression of the murine target genes
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