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Applications of the genO‑panhCD3/hPD-1 mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, immuno-inflammation and autoimmunity:
- Assess the efficacy of diverse compounds such as:
- T-cell engagers targeting both hCD3 and hPD-1
- Therapeutics targeting hPD-1, such as bispecific antibodies and immune checkpoint inhibitors
- Evaluate the safety of therapeutics, such as inducing cytokine release syndrome (CRS) via treatment with hCD3-targeting antibodies
- Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits
Features
- Physiological expression of human CD3 and human PD-1
- Functional CD3/TCR interaction
- Functional T/B cell cooperation
- Fully functional, and with unchanged homeostasis, mouse immune system
- Lack of expression of the murine target genes
Guide: Compare CD3 mouse models for T-cell engager efficacy and safety studies. Read the guide →
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