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Applications of the genO‑hFcγR/hFcRn mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, infectious diseases, inflammation and autoimmunity:
- Assess the efficacy of different antibodies and T-cell engagers:
- Evaluation of B cell depletion following treatment with anti-CD20 antibodies
- Testing the protective role of antibodies in the context of infection, such as influenza
- Ex vivo assessment of antibody-dependent cellular cytotoxicity (ADCC) induced by different monoclonal antibodies
- Ranking antibodies by accessing different binding affinities
- Gaining insight into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefit
Features
- genO‑hFcγR/hIgG1 mice have a human-like FcγR expression pattern and express the humanized constant domain of the IgG1 heavy chain and the IgG1 variable domains
- The IgG1 light chain remains murine
- Functional receptors enable the assessment of Fc-mediated effector functions
- Preservation of the Ig class switching mechanism
- No expression of murine FcγR nor murine IgG1
- Fully immunocompetent model
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