（エボテック）免疫系においてヒト化されたマウスは、治療用抗体開発のための検証済みツールである

要旨

背景

Therapeutic antibodies modulating the immune response are frequently specific for human proteins but fail to cross-react with the corresponding rodent homologs. Hence, their preclinical development requires suitable “humanized” mouse models, i.e. mice bearing a human immune system, so that immunotherapies can be evaluated in a more relevant immune context in vivo. Such “humanized” mice are developed by reconstituting the immune system of immunodeficient animals with human immune cells from 2 possible origins: mature peripheral blood mononuclear cells prepared from buffy coats (huPBMC mice) or CD34⁺ hematopoietic stem cells (huCD34⁺ mice) isolated from cord blood. According to the compound to be tested and the goal of the research, one model may be preferred over the other.