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genO‑hFcγR
Humanized mice (target-specific)

Preclinical humanized genO‑hFcγR mouse model

Preclinical humanized Fc-gamma receptor (genO‑hFcγR) model enabling the assessment of Fc receptor pathways targeted therapies.

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Applications of the genO‑hFcγR mouse model

Broad range of applications in the fields of immuno-oncology, infectious diseases, inflammation and autoimmunity:

  • Assess the Fc-mediated effector function of biologics:
    • Evaluation of B-cell depletion following treatment with anti-CD20 antibodies
    • Testing the protective role of antibodies in the context of infection, such as influenza
    • Ex vivo assessment of antibody-dependent cellular cytotoxicity (ADCC) induced by different monoclonal antibodies
  • Rank Fc-engineered antibodies with enhanced or reduced binding to FcγR
  • Gain insight into the mechanism of action (MOA) of biologics

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Features

  • Fully immunocompetent model
  • genO‑hFcγR mice have a human-like expression pattern
  • No expression of murine FcγR
  • Functional receptors enabling assessment of Fc-mediated effector functions

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Clients

argenx

Scientific articleScientific articlePosterPoster

Vir Biotechnology

Scientific articleScientific articlePosterPoster

VIB

Scientific articleScientific articlePosterPoster

Innate Pharma

Scientific articleScientific articlePosterPoster

Model Delivery & Care

  • Read our FAQ on delivery & care here
  • Orders are made directly with genOway; breeding, housing and delivery are outsourced
  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders

Validation data

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Preclinical humanized genO‑hFcγR mouse model

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Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

Generated with biopharma partners and in-house

Innovative technologies

and guaranteed freedom to operate

Easy access to models

Models with certified health status from professional breeders in US and Europe