Publications 2021-23

Client publication

genOway has been acknowledged in numerous articles for the generation of mouse, rat, and cell line models.

Here, a selection of these publications:

Sevasti Gaspari, Gwenaël Labouèbe, Alexandre Picard, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Bernard Thorens.
Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia.
EMBO Rep. 2023 Jun 14

Kathleen M C Sullivan, Marta Vilalta, Linda S Ertl, Yu Wang, Carolyn Dunlap, Karen Ebsworth, Bin N Zhao, Shijie Li, Yibin Zeng, Zhenhua Miao, Pingchen Fan, Venkat Mali, Christopher Lange, Darren McMurtrie, Ju Yang, Rebecca Lui, Ryan Scamp, Vicky Chhina, Alice Kumamoto, Simon Yau, Ton Dang, Ashton Easterday, Shirley Liu, Shichang Miao, Israel Charo, Thomas J Schall, Penglie Zhang.
CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity.
PLoS One. 2023 Jun 7

Mireia Medrano, Wissal Allaoui, Mathias Van Bulck, Sofie Thys, Leila Makrini-Maleville, Eve Seuntjens, Winnok H De Vos, Emmanuel Valjent, Bálazs Gaszner, Ann Van Eeckhaut, Ilse Smolders, Dimitri De Bundel.
Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells.
Open Biol. 2023 Jun

Kacey J Prentice, Alexandra Lee, Paulina Cedillo, Karen E Inouye, Meric Erikci Ertunc, Jillian K Riveros, Grace Yankun Lee, Gökhan S Hotamisligil.
Sympathetic tone dictates the impact of lipolysis on FABP4 secretion.
J Lipid Res. 2023 Jun

Rui Sun, Siying Guo, Yoko Shuda, Anish B Chakka, Lora H Rigatti, Guangyi Zhao, Mohammed A E Ali, Christopher Y Park, Uma Chandran, Jian Yu, Christopher J Bakkenist, Masahiro Shuda, Patrick S Moore, Yuan Chang.
Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice.
PLoS One. 2023 May 5

Michael C Warren, Stephan Matissek, Matthew Rausch, Marisella Panduro, R J Hall, Austin Dulak, David Brennan, Sonia Das Yekkirala, Secil Koseoglu, Ricard Masia, Yu Yang, Navamallika Reddy, Robert Prenovitz, Jamie Strand, Tauqueer Zaidi, Erik Devereaux, Célia Jacoberger Foissac, John Stagg, Benjamin H Lee, Pamela Holland, Vito J Palombella, Andrew C Lake.
SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties.
Immunohorizons. 2023 May 1

Julia Reichelt, Wiebke Sachs, Sarah Frömbling, Julia Fehlert, Maja Studencka-Turski, Anna Betz, Desiree Loreth, Lukas Blume, Susanne Witt, Sandra Pohl, Johannes Brand, Maire Czesla, Jan Knop, Bogdan I Florea, Stephanie Zielinski, Marlies Sachs, Elion Hoxha, Irm Hermans-Borgmeyer, Gunther Zahner, Thorsten Wiech, Elke Krüger, Catherine Meyer-Schwesinger.
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis.
Nat Commun. 2023 Apr 13

Zhichao Ni, Lingxia Lyu, Hui Gong, Luping Du, Zuoshi Wen, Hua Jiang, Hao Yang, Yanhua Hu, Bohuan Zhang, Qingbo Xu, Xiaogang Guo, Ting Chen.
Multilineage commitment of Sca-1+ cells in reshaping vein grafts.
Theranostics. 2023 Apr 1

Itziar Terradillos, Itziar Bonilla-Del Río, Nagore Puente, Maitane Serrano, Amaia Mimenza, Leire Lekunberri, Ilazki Anaut-Lusar, Leire Reguero, Inmaculada Gerrikagoitia, Samuel Ruiz de Martín Esteban, Cecilia J Hillard, María T Grande, Julián Romero, Izaskun Elezgarai, Pedro Grandes.
Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease.
Glia. 2023 Apr

Matthew P Harris, Shemin Zeng, Zhiyong Zhu, Vitor A Lira, Liping Yu, Denice M Hodgson-Zingman, Leonid V Zingman.
Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning.
Int J Mol Sci. 2023 Mar 30

Flora Crozet, Gaëlle Letort, Rose Bulteau, Christelle Da Silva, Adrien Eichmuller, Anna Francesca Tortorelli, Joséphine Blévinal, Morgane Belle, Julien Dumont, Tristan Piolot, Aurélien Dauphin, Fanny Coulpier, Alain Chédotal, Jean-Léon Maître, Marie-Hélène Verlhac, Hugh J Clarke, Marie-Emilie Terret.
Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes.
Life Sci Alliance. 2023 Mar 21

Carl J May, Musleeha Chesor, Sarah E Hunter, Bryony Hayes, Rachel Barr, Tim Roberts, Fern A Barrington, Louise Farmer, Lan Ni, Maisie Jackson, Heidi Snethen, Nadia Tavakolidakhrabadi, Max Goldstone, Rodney Gilbert, Matt Beesley, Rachel Lennon, Rebecca Foster, Richard Coward, Gavin I Welsh, Moin A Saleem.
Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events.
Kidney Int. 2023 Mar 20

Simon Cao, Michael J Jurczak, Yoko Shuda, Rui Sun, Masahiro Shuda, Yuan Chang, Patrick S Moore.
Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice.
PLoS One. 2023 Mar 10

Sarah Bauer, Vanessa Aeissen, Alena M Bubeck, Ioannis Kienes, Kornelia Ellwanger, Mona Scheurenbrand, Fjolla Rexhepi, Sheela Ramanathan, Philip Rosenstiel, W Florian Fricke, Thomas A Kufer.
NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes.
iScience. 2023 Mar 2

Pernille Kristine Fisker Christensen, Axel Kornerup Hansen, Søren Skov, Britta Cathrina Martel, Jesper Larsen, Maria Helena Høyer-Hansen, Janne Koch.
Imiquimod induces skin inflammation in humanized BRGSF mice with limited human immune cell activity.
PLoS One. 2023 Feb 17

Marc L Purazo, Ryan J Ice, Rahul Shimpi, Mark Hoenerhoff, Elena N Pugacheva.
NEDD9 Overexpression Causes Hyperproliferation of Luminal Cells and Cooperates with HER2 Oncogene in Tumor Initiation: A Novel Prognostic Marker in Breast Cancer.
Cancers (Basel). 2023 Feb 9

Chiahsuan Chin, Ranjithkumar Ravichandran, Kristina Sanborn, Timothy Fleming, Stephen B Wheatcroft, Mark T Kearney, Sofya Tokman, Rajat Walia, Michael A Smith, David J Flint, Thalachallour Mohanakumar, Ross M Bremner, Angara Sureshbabu.
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.
Cell Rep Med. 2023 Feb 9

Doumet Georges Helou, Christine Quach, Marshall Fung, Jacob D Painter, Benjamin P Hurrell, Yong-Hwee Eddie Loh, Emily Howard, Pedram Shafiei-Jahani, Pejman Soroosh, Arlene H Sharpe, Omid Akbari.
Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells.
J Allergy Clin Immunol. 2023 Feb

Christoph Hudemann, Yvonne Exner, Robert Pollmann, Karina Schneider, Anna Zakrzewicz, Simon Feldhoff, Thomas Schmidt, Volker Spindler, David Rafei-Shamsabadi, Frauke Völlner, Jens Waschke, Ritva Tikkanen, Michael Hertl, Rüdiger Eming.
IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris.
J Invest Dermatol. 2023 Feb

Maja L Nybo, Jone M Kvam, John E Nielsen, Hanne Frederiksen, Katja Spiess, Kristian H R Jensen, Sarina Gadgaard, Anna L S Walser, Jesper S Thomsen, Pamela Cowin, Anders Juul, Martin Blomberg Jensen, Mette M Rosenkilde.
Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.
FASEB J. 2023 Feb

Jina Yun, Simon Hansen, Otto Morris, David T Madden, Clare Peters Libeu, Arjun J Kumar, Cameron Wehrfritz, Aaron H Nile, Yingnan Zhang, Lijuan Zhou, Yuxin Liang, Zora Modrusan, Michelle B Chen, Christopher C Overall, David Garfield, Judith Campisi, Birgit Schilling, Rami N Hannoush, Heinrich Jasper.
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
Nat Commun. 2023 Jan 11

Chutima Jansakun, Warangkana Chunglok, Sandro Altamura, Martina Muckenthaler, Simone Staffer, Sabine Tuma-Kellner, Uta Merle, Walee Chamulitrat.
Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH.
JBiochim Biophys Acta Mol Basis Dis. 2023 Jan 1

Karianne Fjeld, Anny Gravdal, Ranveig S Brekke, Jahedul Alam, Steven J Wilhelm, Khadija El Jellas, Helene N Pettersen, Jianguo Lin, Marie H Solheim, Solrun J Steine, Bente B Johansson, Pål R Njølstad, Caroline S Verbeke, Xunjun Xiao, Mark E Lowe, Anders Molven.
The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice.
Pancreatology. 2022 Dec

Jun W Kim, Julie H Ko, Julien Sage.
DLL3 regulates Notch signaling in small cell lung cancer.
iScience. 2022 Nov 16

Frédéric Adam, Alexandre Kauskot, Lamia Lamrani, Jean Solarz, Christelle Soukaseum, Christelle Repérant, Cécile V Denis, Hana Raslova, Jean-Philippe Rosa, Marijke Bryckaert.
A gain-of-function filamin A mutation in mouse platelets induces thrombus instability.
J Thromb Haemost. 2022 Nov

Elisabeth Fuchs, Imke Rudnik-Jansen, Anders Dinesen, Denis Selnihhin, Ole Aalund Mandrup, Kader Thiam, Jørgen Kjems, Finn Skou Pedersen, Kenneth A Howard.
An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension.
Acta Biomater. 2022 Nov

Arianne Papa, Sergey I Zakharov, Alexander N Katchman, Jared S Kushner, Bi-Xing Chen, Lin Yang, Guoxia Liu, Alejandro Sanchez Jimenez, Robyn J Eisert, Gary A Bradshaw, Wen Dun, Shah R Ali, Aaron Rodriques, Karen Zhou, Veli Topkara, Mu Yang, John P Morrow, Emily J Tsai, Arthur Karlin, Elaine Wan, Marian Kalocsay, Geoffrey S Pitt, Henry M Colecraft, Manu Ben-Johny, Steven O Marx.
Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response.
Nat Cardiovasc Res. 2022 Nov

Nicholas L Weilinger, Leigh E Wicki-Stordeur, Christopher J Groten, Jeffrey M LeDue, Kristopher T Kahle, Brian A MacVicar.
KCC2 drives chloride microdomain formation in dendritic blebbing.
Cell Rep. 2022 Oct 25

Ju Youn Kim, Lily Q Wang, Valentina C Sladky, Tae Gyu Oh, Junlai Liu, Kaitlyn Trinh, Felix Eichin, Michael Downes, Mojgan Hosseini, Etienne D Jacotot, Ronald M Evans, Andreas Villunger, Michael Karin.
PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis.
Cell Metab. 2022 Oct 4

Adeline Sivignon, Mélissa Chervy, Caroline Chevarin, Elia Ragot, Elisabeth Billard, Jérémy Denizot, Nicolas Barnich.
An adherent-invasive Escherichia coli-colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease.
Dis Model Mech. 2022 Oct 1

Anastasiya Strembitska, Gwenaël Labouèbe, Alexandre Picard, Xavier P Berney, David Tarussio, Maxime Jan, Bernard Thorens.
Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion.
Nat Commun. 2022 Sep 30

Margarita Brilkova, Martina Nigri, Harshitha Santhosh Kumar, James Moore, Matilde Mantovani, Claudia Keller, Amandine Grimm, Anne Eckert, Dimitri Shcherbakov, Rashid Akbergenov, Petra Seebeck, Stefanie D Krämer, David P Wolfer, Thomas C Gent, Erik C Böttger.
Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice.
Cell Rep. 2022 Sep 27

Dasom Kim, Jin-Ho Park, Tae-Yoon Kim, Dong-Gun Kim, June-Ho Byun, Hak-Sung Kim.
Enhanced half-life and antitumor activity of interleukin-15 through genetic fusion of a serum albumin-specific protein binder.
Int J Pharm. 2022 Sep 25

YouJin Lee, Morgan R Miller, Marty A Fernandez, Elizabeth L Berg, Adriana M Prada, Qing Ouyang, Michael Schmidt, Jill L Silverman, Tracy L Young-Pearse, Eric M Morrow.
Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain.
Brain. 2022 Sep 14

Marco Piroth, Daniel J Gorski, Christian Hundhausen, Anne Petz, Simone Gorressen, Dominik Semmler, Heba Zabri, Sonja Hartwig, Stefan Lehr, Malte Kelm, Christian Jung, Jens W Fischer.
Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
Matrix Biol. 2022 Sep

Kris Genelyn Dimasuay, Niccolette Schaunaman, Bruce Berg, Diana Cervantes, Elke Kruger, Frank L Heppner, Deborah A Ferrington, Hong Wei Chu.
Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection.
Sci Rep. 2022 Aug 25

Claudia S Bauer, Rebecca N Cohen, Francesca Sironi, Matthew R Livesey, Thomas H Gillingwater, J Robin Highley, Daniel J Fillingham, Ian Coldicott, Emma F Smith, Yolanda B Gibson, Christopher P Webster, Andrew J Grierson, Caterina Bendotti, Kurt J De Vos.
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD.
Acta Neuropathol. 2022 Jul 25

Yinmao Chi, Xiuli Zhang, Dan Liang, Yue Wang, Xiaoyi Cai, Jiqiu Dong, Lingzhi Li, Zhihong Chi.
TZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways
Biol Trace Elem Res. 2022 Jul 23

Julia Leschik, Antonietta Gentile, Cigdem Cicek, Sophie Péron, Margaryta Tevosian, Annika Beer, Konstantin Radyushkin, Anna Bludau, Karl Ebner, Inga Neumann, Nicolas Singewald, Benedikt Berninger, Volkmar Lessmann, Beat Lutz.
Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis
Prog Neurobiol. 2022 Jul 21

Torben Johann Hausrat, Philipp C Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneussel.
Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice
Nat Commun. 2022 Jul 20

Ann Hanna, Mellissa J Nixon, M Valeria Estrada, Violeta Sanchez, Quanhu Sheng, Susan R Opalenik, Abigail L Toren, Joshua Bauer, Phillip Owens, Frank M Mason, Rebecca S Cook, Melinda E Sanders, Carlos L Arteaga, Justin M Balko.
Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer
Breast Cancer Res. 2022 Jul 18

Rita C Acúrcio, Sabina Pozzi, Barbara Carreira, Marta Pojo, Nuria Gómez-Cebrián, Sandra Casimiro, Adelaide Fernandes, Andreia Barateiro, Vitor Farricha, Joaquim Brito, Ana Paula Leandro, Jorge A R Salvador, Luís Graça, Leonor Puchades-Carrasco, Luís Costa, Ronit Satchi-Fainaro, Rita C Guedes, Helena F Florindo.
Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment
J Immunother Cancer. 2022 Jul

Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S H Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso, Michael Potente.
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth
Nat Metab. 2022 Jun

S Bullich, P de Souto Barreto, A Dortignac, L He, C Dray, P Valet, B P Guiard.
Apelin controls emotional behavior in age- and metabolic state-dependent manner.
Psychoneuroendocrinology. 2022 Jun

Lai Wen, Alex Marki, Zhihao Wang, Marco Orecchioni, Jeffrey Makings, Monica Billitti, Erpei Wang, Sujit S A Suthahar, Kenneth Kim, William B Kiosses, Zbigniew Mikulski, Klaus Ley.
A humanized β 2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in vivo.
Cell Rep. 2022 May 31

C Macchi, A Moregola, M F Greco, M Svecla, F Bonacina, S Dhup, R K Dadhich, M Audano, P Sonveaux, C Mauro, N Mitro, M Ruscica, G D Norata.
Monocarboxylate transporter 1 deficiency impacts CD8+ T lymphocytes proliferation and recruitment to adipose tissue during obesity.
iScience. 2022 May 23

Reda Juskeviciene, Ann-Kristina Fritz, Margarita Brilkova, Rashid Akbergenov, Karen Schmitt, Hubert Rehrauer, Endre Laczko, Patricia Isnard-Petit, Kader Thiam, Anne Eckert, Jochen Schacht, David P Wolfer, Erik C Böttger, Dimitri Shcherbakov.
Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.
Int J Mol Sci. 2022 Apr 15

Francesca Mateo, Zhengcheng He, Lin Mei, Gorka Ruiz de Garibay, Carmen Herranz, Nadia García, Amanda Lorentzian, Alexandra Baiges, Eline Blommaert, Antonio Gómez, Oriol Mirallas, Anna Garrido-Utrilla, Luis Palomero, Roderic Espín, Ana I Extremera, M Teresa Soler-Monsó, Anna Petit, Rong Li, Joan Brunet, Ke Chen, Susanna Tan, Connie J Eaves, Curtis McCloskey, Razq Hakem, Rama Khokha, Philipp F Lange, Conxi Lázaro, Christopher A Maxwell, Miquel Angel Pujana.
Modification of BRCA1-associated breast cancer risk by HMMR overexpression.
Nat Commun. 2022 Apr 7

Álvaro Sebastián-Serrano, Jesús Merchán-Rubira, Caterina Di Lauro, Carolina Bianchi, Lucía Soria-Tobar, Sonoko Narisawa, José L Millán, Jesús Ávila, Félix Hernández, Miguel Díaz-Hernández.
TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy
Neurobiol Dis. 2022 Apr

Inwoo Hwang, Byeong-Seong Kim, Hyo Rim Ko, Seongbong Cho, Ho Yun Lee, Sung-Woo Cho, Dongryeol Ryu, Sungbo Shim, Jee-Yin Ahn.
Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.
Mol Psychiatry. 2022 Apr

Isabel Fernández-Pisonero, Laura Clavaín, Javier Robles-Valero, L Francisco Lorenzo-Martín, Rubén Caloto, Blanca Nieto, Carmen García-Macías, Clara L Oeste, Manuel Sánchez-Martín, Antonio Abad, Alejandro Hortal, Dolores Caballero, Marcos González, Mercedes Dosil, Balbino Alarcón, Xosé R Bustelo.
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
Cell Rep. 2022 Mar 15

Sarah Chan, Nicole Belmar, Sun Ho, Bryan Rogers, Marcia Stickler, Michelle Graham, Eileen Lee, Ninian Tran, Dong Zhang, Priyanka Gupta, Mien Sho, Tracy MacDonough, Andrew Woolley, Han Kim, Hong Zhang, Wei Liu, Pingping Zheng, Zoltan Dezso, Kyle Halliwill, Michele Ceccarelli, Susan Rhodes, Archana Thakur, Charles M Forsyth, Mengli Xiong, Siu Sze Tan, Ramesh Iyer, Marc Lake, Enrico Digiammarino, Li Zhou, Lance Bigelow, Kenton Longenecker, Russell A Judge, Cassie Liu, Max Trumble, Jonathan P Remis, Melvin Fox, Belinda Cairns, Yoshiko Akamatsu, Diane Hollenbaugh, Fiona Harding, Hamsell M Alvarez.
An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy
Nat Cancer. 2022 Mar 7

Dimitri Shcherbakov, Martina Nigri, Rashid Akbergenov, Margarita Brilkova, Matilde Mantovani, Patricia Isnard Petit, Amandine Grimm, Agnieszka A Karol, Youjin Teo, Adrián Cortés Sanchón, Yadhu Kumar, Anne Eckert, Kader Thiam, Petra Seebeck, David P Wolfer, Erik C Böttger.
Premature aging in mice with error-prone protein synthesis
Sci Adv. 2022 Mar 4

Julie A Zorn, Matthew L Wheeler, Ralston M Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y-C Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop.
Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model
Sci Rep. 2022 Mar 3

Andrea Vogel, Katharina Martin, Klara Soukup, Angela Halfmann, Martina Kerndl, Julia S Brunner, Melanie Hofmann, Laura Oberbichler, Ana Korosec, Mario Kuttke, Hannes Datler, Markus Kieler, Laszlo Musiejovsky, Alexander Dohnal, Omar Sharif, Gernot Schabbauer.
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction
Cell Rep. 2022 Feb 22

Patricia Sansilvestri Morel, Valerie Duvivier, Florence Bertin, Nicolas Provost, Adel Hammoutene, Edwige-Ludiwyne Hubert, Arantxa Gonzalez, Isabelle Tupinon-Mathieu, Valerie Paradis, Philippe Delerive.
Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression
PLoS One. 2022 Feb 11

Alejandro M Hortal, Clara L Oeste, Claudia Cifuentes, Miguel Alcoceba, Isabel Fernández-Pisonero, Laura Clavaín, Rut Tercero, Pilar Mendoza, Verónica Domínguez, Marta García-Flores, Belén Pintado, David Abia, Carmen García-Macías, Almudena Navarro-Bailón, Xosé R Bustelo, Marcos González, Balbino Alarcón.
Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia
Mol Cancer. 2022 Feb 4

Gonzalo Garcia-Martin, Miriam Sanz-Rodriguez, Berta Alcover-Sanchez, Marta P Pereira, Francisco Wandosell, Beatriz Cubelos.
R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System
Int J Mol Sci. 2022 Jan 17

Alexandre Bacq, Delphine Roussel, Thomas Bonduelle, Sara Zagaglia, Marina Maletic, Théo Ribierre, Homa Adle-Biassette, Cécile Marchal, Mélanie Jennesson, Isabelle An, Genomics England Research Consortium; Fabienne Picard, Vincent Navarro, Sanjay M Sisodiya, Stéphanie Baulac.
Cardiac Investigations in Sudden Unexpected Death in DEPDC5-Related Epilepsy
Ann Neurol. 2022 Jan

Valentina Poli, Marco Di Gioia, Martha Sola-Visner, Francesca Granucci, Andrew L Frelinger 3rd, Alan D Michelson, Ivan Zanoni.
Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia
Immunity. 2021 Dec 24

Bernard Lassègue, Sandeep Kumar, Rohan Mandavilli, Keke Wang, Michelle Tsai, Dong-Won Kang, Catherine Demos, Marina S Hernandes, Alejandra San Martín, W Robert Taylor, Hanjoong Jo, Kathy K Griendling.
Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting
PLoS One. 2021 Dec 20

A Fatehullah, Y Terakado, S Sagiraju, T L Tan, T Sheng, S H Tan, K Murakami, Y Swathi, N Ang, R Rajarethinam, T Ming 6, P Tan, B Lee, N Barker.
A tumour-resident Lgr5 + stem-cell-like pool drives the establishment and progression of advanced gastric cancers
Nat Cell Biol. 2021 Dec

Bjoern Traenkle, Philipp D Kaiser, Stefania Pezzana, Jennifer Richardson, Marius Gramlich, Teresa R Wagner, Dominik Seyfried, Melissa Weldle, Stefanie Holz, Yana Parfyonova, Stefan Nueske, Armin M Scholz, Anne Zeck, Meike Jakobi, Nicole Schneiderhan-Marra, Martin Schaller, Andreas Maurer, Cécile Gouttefangeas, Manfred Kneilling, Bernd J Pichler, Dominik Sonanini, Ulrich Rothbauer
Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4 + Cells
Front Immunol. 2021 Dec 9

Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M Snell, Shantha K Mahadevaiah, Obah A Ojarikre, Peter J I Ellis, James M A Turner
CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
Nat Commun. 2021 Dec 3

Li-Chiung Lin, Tezz Quon, Susanna Engberg, Amanda E Mackenzie, Andrew B Tobin, Graeme Milligan
G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes.
ACS Pharmacol Transl Sci. 2021 Nov 30

Beatrice Romier, Cédric Dray, Laetitia Vanalderwiert, Amandine Wahart, Thinhinane Hocine, Alizée Dortignac, Christian Garbar, Corinne Garbar, Camille Boulagnon, Nicole Bouland, Pascal Maurice, Amar Bennasroune, Hervé Sartelet, Laurent Martiny, Laurent Duca, Philippe Valet, Sébastien Blaise.
Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall.
Sci Rep. 2021 Nov 15

Ewoud R E Schmidt, Hanzhi T Zhao, Jung M Park, Mario Dipoppa, Mauro M Monsalve-Mercado, Jacob B Dahan, Chris C Rodgers, Amélie Lejeune, Elizabeth M C Hillman, Kenneth D Miller, Randy M Bruno, Franck Polleux.
A human-specific modifier of cortical connectivity and circuit function.
Nature. 2021 Nov

Claire Pujol, Anne Legrand, Livia Parodi, Priscilla Thomas, Fanny Mochel, Dario Saracino, Giulia Coarelli, Marijana Croon, Milica Popovic, Manon Valet, Nicolas Villain, Shahira Elshafie, Mahmoud Issa, Stephane Zuily, Mathilde Renaud, Cécilia Marelli-Tosi, Marine Legendre, Aurélien Trimouille, Isabelle Kemlin, Sophie Mathieu, Joseph G Gleeson, Foudil Lamari, Daniele Galatolo, Rana Alkouri, Chantal Tse, Diana Rodriguez, Claire Ewenczyk, Florence Fellmann, Thierry Kuntzer, Emilie Blond, Khalid H El Hachimi, Frédéric Darios, Alexandre Seyer, Anastasia D Gazi, Patrick Giavalisco, Silvina Perin, Jean-Luc Boucher, Laurent Le Corre, Filippo M Santorelli, Cyril Goizet, Maha S Zaki, Serge Picaud, Arnaud Mourier, Sophie Marie Steculorum, Cyril Mignot, Alexandra Durr, Aleksandra Trifunovic, Giovanni Stevanin.
Implication of folate deficiency in CYP2U1 loss of function.
J Exp Med. 2021 Nov 1

Yannick Fotio, Kwang-Mook Jung, Francesca Palese, Andre Obenaus, Alex Mabou Tagne, Lin Lin, Tarif Ibne Rashid, Romario Pacheco, Amandine Jullienne, Jade Ramirez, Marco Mor, Gilberto Spadoni, Cholsoon Jang, Andrea G Hohmann, Daniele Piomelli.
NAAA-regulated lipid signaling governs the transition from acute to chronic pain.
Sci Adv. 2021 Oct 22

Yasemin Özgür-Günes, Catherine Le Stunff, Malha Chedik, Marie-Pierre Belot, Pierre-Hadrien Becker, Véronique Blouin, Pierre Bougnères.
Correction of a knock-in mouse model of acrodysostosis with gene therapy using a rAAV9-CAG-human PRKAR1A vector.
Gene Ther. 2021 Oct 1

Nguyen Huu Tu, Kenji Inoue, Elyssa Chen, Bethany M Anderson, Caroline M Sawicki, Nicole N Scheff, Hung D Tran, Dong H Kim, Robel G Alemu, Lei Yang, John C Dolan, Cheng Z Liu, Malvin N Janal, Rocco Latorre, Dane D Jensen, Nigel W Bunnett, Laura E Edgington-Mitchell, Brian L Schmidt.
Cathepsin S Evokes PAR 2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models.
Cancers (Basel). 2021 Sep 19

Barbara Ben Yamin, Sana Ahmed-Seghir, Junya Tomida, Emmanuelle Despras, Caroline Pouvelle, Andrey Yurchenko, Jordane Goulas, Raphael Corre, Quentin Delacour, Nathalie Droin, Philippe Dessen, Didier Goidin, Sabine S Lange, Sarita Bhetawal, Maria Teresa Mitjavila-Garcia, Giuseppe Baldacci, Sergey Nikolaev, Jean Charles Cadoret, Richard D Wood, Patricia L Kannouche.
DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability.
EMBO J. 2021 Sep 17

Ling Liu, Cristina Rodriguez-Mateo, Polly Huang, Albin Huang, Alexander Lieu, Michelle Mao, Mingyu Chung, Sharon Yang, Kevin Yu, Gregory W Charville, Qiang Gan, Thomas A Rando.
Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist.
Proc Natl Acad Sci U S A. 2021 Sep 14

Christian Smolka, Delia Schlösser, Catherine Hohnloser, Xavier Bemtgen, Caterina Jänich, Laura Schneider, Julien Martin, Dietmar Pfeifer, Martin Moser, Peter Hasselblatt, Christoph Bode, Sebastian Grundmann, Franziska Pankratz.
MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice.
Mol Med. 2021 Sep 6

Christian Hundhausen, Rebekka Schneckmann, Yanina Ostendorf, Jacqueline Rimpler, Anette von Glinski, Christina Kohlmorgen, Nina Pasch, Luca Rolauer, Florian von Ameln, Olaf Eckermann, Joachim Altschmied, Niloofar Ale-Agha, Judith Haendeler, Ulrich Flögel, Jens W Fischer, Maria Grandoch.
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease.
Matrix Biol. 2021 Aug 28

Tina Schreiber, Maren Falk-Paulsen, Jan Kuiper, Konrad Aden, Rainer Noth, Nicolas Gisch, Stefan Schreiber, Philip Rosenstiel, Burkhard Bewig.
IL23R on myeloid cells is involved in murine pulmonary granuloma formation.
Exp Lung Res. 2021 Aug 18

Noureddine Ben Khalaf, Wedad Al-Mashoor, Azhar Saeed, Wassim Raslan, Halla Bakheit, Ameera Abdulhadi, Ammar Marouani, Safa Taha, Moiz Bakhiet, M Dahmani Fathallah.
Knocking down Israa, the Zmiz1 intron-nested gene, unveils interrelated T cell activation functions in mouse.
Biochem Biophys Rep. 2021 Aug 9

Christoph S Clemen, Andreas Schmidt, Lilli Winter, Fabio Canneva, Ilka Wittig, Lore Becker, Roland Coras, Carolin Berwanger, German Mouse Clinic Consortium; Andreas Hofmann, Britta Eggers, Katrin Marcus, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Marcus Krüger, Stephan von Hörsten, Ludwig Eichinger, Rolf Schröder.
N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue.
Neuropathol Appl Neurobiol. 2021 Jul 27

Marwa Mahmoud, Ian Evans, Laura Wisniewski, Yuen Tam, Claire Walsh, Simon Walker-Samuel, Paul Frankel, Peter Scambler, Ian Zachary.
Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.
Cardiovasc Res. 2021 Jul 16

Deng Pan, Miles Bichanich, Ian S Wood, Daniel A Hunter, Scott M Tintle, Thomas A Davis, Matthew D Wood, Amy M Moore.
Long Acellular Nerve Allografts Cap Transected Nerve to Arrest Axon Regeneration and Alter Upstream Gene Expression in a Rat Neuroma Model.
Plast Reconstr Surg. 2021 Jul 1

Peter Lehmkuhl, Magdalena Gentz, Andres Caballero Garcia de Otezya, Bodo Grimbacher, Hendrik Schulze-Koops, Alla Skapenko.
Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32.
Cell Mol Immunol. 2021 Jul

Alex Lipovsky, Peter F Slivka, Zhi Su, Yibing Wang, Stephanie Paulsboe, Joseph Wetter, Marian T Namovic, Donna Gauvin, Denise Perron, Stephen B Gauld, Steven McGaraughty, Eric R Goedken.
ACT1 Is Required for Murine IL-23-Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity.
J Invest Dermatol. 2021 Jul

Olivia Sveidahl Johansen, Tao Ma, Jakob Bondo Hansen, Lasse Kruse Markussen, Renate Schreiber, Laia Reverte-Salisa, Hua Dong, Dan Ploug Christensen, Wenfei Sun, Thorsten Gnad, Iuliia Karavaeva, Thomas Svava Nielsen, Sander Kooijman, Cheryl Cero, Oksana Dmytriyeva, Yachen Shen, Maria Razzoli, Shannon L O'Brien, Eline N Kuipers, Carsten Haagen Nielsen, William Orchard, Nienke Willemsen, Naja Zenius Jespersen, Morten Lundh, Elahu Gosney Sustarsic, Cecilie Mørch Hallgren, Mikkel Frost, Seth McGonigle, Marie Sophie Isidor, Christa Broholm, Oluf Pedersen, Jacob Bo Hansen, Niels Grarup, Torben Hansen, Andreas Kjær, James G Granneman, M Madan Babu, Davide Calebiro, Søren Nielsen, Mikael Rydén, Raymond Soccio , Patrick C N Rensen, Jonas Thue Treebak, Thue Walter Schwartz, Brice Emanuelli, Alessandro Bartolomucci, Alexander Pfeifer, Rudolf Zechner, Camilla Scheele, Susanne Mandrup, Zachary Gerhart-Hines.
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Cell. 2021 Jun 24

Harini Ramalingam, Sonu Kashyap, Patricia Cobo-Stark, Andrea Flaten, Chun-Mien Chang, Sachin Hajarnis, Kyaw Zaw Hein, Jorgo Lika, Gina M Warner, Jair M Espindola-Netto, Ashwani Kumar, Mohammed Kanchwala, Chao Xing, Eduardo N Chini, Vishal Patel.
A methionine-Mettl3-N 6-methyladenosine axis promotes polycystic kidney disease.
Cell Metab. 2021 Jun 1

Dustin J Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J Willis, Kathryn Gilroy, Alexander P Raven, Lynn Mcgarry, Johanna I Englund, Anna T Webb, Sandra Scharaw, Nadia Nasreddin, Michael C Hodder, Rachel A Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K Najumudeen, Beatrice Romagnolo, Christine Perret, Ann C Williams, Hans Clevers, Pirjo Nummela, Marianne Lähde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, E Yvonne Jones, Ari Ristimäki, Simon J Leedham, Paul V Fish, Jean-Paul Vincent, Pekka Katajisto, Owen J Sansom.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Nature. 2021 Jun

Aditi R Saxena, Donal N Gorman, Ryan M Esquejo, Arthur Bergman, Kristin Chidsey, Clare Buckeridge, David A Griffith, Albert M Kim.
Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial.
Nat Med. 2021 Jun

Qinchuan Wang, Erick O Hernández-Ochoa, Meera C Viswanathan, Ian D Blum, Danh C Do, Jonathan M Granger, Kevin R Murphy, An-Chi Wei, Susan Aja, Naili Liu, Corina M Antonescu, Liliana D Florea, C Conover Talbot Jr, David Mohr, Kathryn R Wagner, Sergi Regot, Richard M Lovering, Peisong Gao, Mario A Bianchet, Mark N Wu, Anthony Cammarato, Martin F Schneider, Gabriel S Bever, Mark E Anderson.
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.
Nat Commun. 2021 May 26

Michael Shum, Chitra A Shintre, Thorsten Althoff, Vincent Gutierrez, Mayuko Segawa, Alexandra D Saxberg, Melissa Martinez, Roslin Adamson, Margaret R Young, Belinda Faust, Raffi Gharakhanian, Shi Su, Karthickeyan Chella Krishnan, Kiana Mahdaviani, Michaela Veliova, Dane M Wolf, Jennifer Ngo, Laura Nocito, Linsey Stiles, Jeff Abramson, Aldons J Lusis, Andrea L Hevener, Maria E Zoghbi, Elisabeth P Carpenter, Marc Liesa.
ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity.
Sci Transl Med. 2021 May 19

Rebecca A Helmer, Raul Martinez-Zaguilan, Gurvinder Kaur, Lisa A Smith, Jannette M Dufour, Beverly S Chilton.
Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis.
PLoS One. 2021 May 19

Anthony S Castanza, Sanja Ramirez, Prem P Tripathi, Ray A M Daza, Franck K Kalume, Jan-Marino Ramirez, Robert F Hevner.
AUTS2 Regulates RNA Metabolism and Dentate Gyrus Development in Mice.
Cereb Cortex. 2021 May 19

Lisa Baker, Moses Tar, Adam H Kramer, Guillermo A Villegas, Rabab A Charafeddine, Olga Vafaeva, Parimala Nacharaju, Joel Friedman, Kelvin P Davies, David J Sharp.
Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.
JCI Insight. 2021 May 10

Goutam Chandra, Sen Chandra Sreetama, Davi A G Mázala, Karine Charton, Jack H VanderMeulen, Isabelle Richard, Jyoti K Jaiswal.
Endoplasmic reticulum maintains ion homeostasis required for plasma membrane repair.
J Cell Biol. 2021 May 3

Simon J Dovedi, Matthew J Elder, Chunning Yang, Suzanne I Sitnikova, Lorraine Irving, Anna Hansen, James Hair, Des C Jones, Sumati Hasani, Bo Wang, Seock-Ah Im, Ben Tran, Deepa S Subramaniam, Shelby D Gainer, Kapil Vashisht, Arthur Lewis, Xiaofang Jin, Stacy Kentner, Kathy Mulgrew, Yaya Wang, Michael G Overstreet, James Dodgson, Yanli Wu, Asis Palazon, Michelle Morrow, Godfrey J Rainey, Gareth J Browne, Frances Neal, Thomas V Murray, Aleksandra D Toloczko, William Dall'Acqua, Ikbel Achour, Daniel J Freeman, Robert W Wilkinson, Yariv Mazor.
Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1 + Activated T Cells.
Cancer Discov. 2021 May

Jieru Deng, Chunni Lu, Chuanxin Liu, Sara Oveissi, W Douglas Fairlie, Erinna F Lee, Pamuk Bilsel, Hamsa Puthalakath, Weisan Chen.
Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope.
FEBS J. 2021 May

Faik Imeri, Bisera Stepanovska Tanturovska, Stephanie Schwalm, Sarbari Saha, Jinyang Zeng-Brouwers, Herrmann Pavenstädt, Josef Pfeilschifter, Liliana Schaefer, Andrea Huwiler.
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Matrix Biol. 2021 Apr

Caleb N Seavey, Ajaybabu V Pobbati, Andrea Hallett, Shuang Ma, Jordan P Reynolds, Ryan Kanai, John M Lamar, Brian P Rubin.
WWTR1(TAZ)- CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis.
Genes Dev. 2021 Apr 1

Talat H Malik, Daniel P Gitterman 2, Deborah P Lavin, Hannah J Lomax-Browne, E Christina Hiemeyer, Linda B Moran, Katharina Boroviak, H Terence Cook, Alyssa C Gilmore, Mawj Mandwie, Amina Ahmad, Ian E Alexander, Grant J Logan, Kevin J Marchbank, Allan Bradley, Matthew C Pickering.
Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.
Proc Natl Acad Sci U S A. 2021 Mar 30

Faik Imeri, Bisera Stepanovska Tanturovska, Aleksandra Zivkovic, Gaby Enzmann, Stephanie Schwalm, Josef Pfeilschifter, Thomas Homann, Burkhard Kleuser, Britta Engelhardt, Holger Stark, Andrea Huwiler.
Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis.
Neuropharmacology. 2021 Mar 15

Maryam Keshavarz, Diethard Tautz.
The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice.
Proc Natl Acad Sci U S A. 2021 Mar 9

Ole A Mandrup, Sui Ching Ong, Simon Lykkemark, Anders Dinesen, Imke Rudnik-Jansen, Niels Frederik Dagnæs-Hansen, Jan Terje Andersen, Luis Alvarez-Vallina, Kenneth A Howard.
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity.
Commun Biol. 2021 Mar 8

Lukas Huijbregts, Virginie Aiello, Andrea Soggia, Philippe Ravassard, Latif Rachdi, Raphaël Scharfmann, Olivier Albagli.
Culture, differentiation, and transduction of mouse E12.5 pancreatic spheres: an in vitro model for the secondary transition of pancreas development.
Islets. 2021 Mar 4

Anastasia Noël, Bénédicte Foveau, Andréa C LeBlanc.
Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits.
Cell Death Dis. 2021 Mar 1

Berta Alcover-Sanchez, Gonzalo Garcia-Martin, Juan Escudero-Ramirez, Carolina Gonzalez-Riano, Paz Lorenzo, Alfredo Gimenez-Cassina1 Laura Formentini, Pedro de la Villa-Polo, Marta P Pereira, Francisco Wandosell, Beatriz Cubelos.
Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model.
Glia. 2021 Mar

Julien C Vantourout, Andrew M Mason, Josephine Yuen, Graham L Simpson, Ghotas Evindar, Letian Kuai, Michael Hobbs, Emma Edgar, Saul Needle, Xiaopeng Bai, Steve Wilson, Paul Scott-Stevens, William Traylen, Kim Lambert, Neil Young, Shenaz Bunally, Scott G Summerfield, Richard Snell, Rakesh Lad, Eric Shi, Steven Skinner, Lisa Shewchuk, Allan J B Watson, Chun-Wa Chung, Sandeep Pal, Dennis A Holt, Lara S Kallander, Joanne Prendergast, Katrina Rivera, David G Washburn, Mark R Harpel, Christopher Arico-Muendel, Albert Isidro-Llobet.
In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders.
Bioconjug Chem. 2021 Feb 17

Valentin Jargaud, Sandy Bour, François Tercé, Xavier Collet, Philippe Valet, Anne Bouloumié, Jean-Claude Guillemot, Pascale Mauriège, Sirpa Jalkanen, Craig Stolen, Marko Salmi, David J Smith, Christian Carpéné.
Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.
J Physiol Biochem. 2021 Feb

Marta Duran-Güell, Roger Flores-Costa, Mireia Casulleras, Cristina López-Vicario, Esther Titos, Alba Díaz, José Alcaraz-Quiles, Raquel Horrillo, Montserrat Costa, Javier Fernández, Vicente Arroyo, Joan Clària.
Albumin protects the liver from tumor necrosis factor α-induced immunopathology.
FASEB J. 2021 Feb

Nguyen Huu Tu, Dane D Jensen, Bethany M Anderson, Elyssa Chen, Nestor N Jimenez-Vargas, Nicole N Scheff, Kenji Inoue, Hung D Tran, John C Dolan, Tamaryn A Meek, Morley D Hollenberg, Cheng Z Liu, Stephen J Vanner, Malvin N Janal, Nigel W Bunnett, Laura E Edgington-Mitchell, Brian L Schmidt.
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
J Neurosci. 2021 Jan 6

genOway is author of the following publications:

Vanessa Chenouard, Séverine Remy, Laurent Tesson, Séverine Ménoret, Laure-Hélène Ouiss, Yacine Cherifi, Ignacio Anegon.
Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models.
Front Genet. 2021 Apr 20.

Henri-Philippe Konan, Loay Kassem, Soleilmane Omarjee, Ausra Surmieliova-Garnès, Julien Jacquemetton, Elodie Cascales, Amélie Rezza, Olivier Trédan, Isabelle Treilleux, Coralie Poulard, Muriel Le Romancer.
ERα-36 Regulates Progesterone Receptor Activity in Breast Cancer.
Breast Cancer Res. 2020 May 19.

Johnston RJ, Su LJ, Pinckney J, Critton D, Boyer E, Krishnakumar A, Corbett M, Rankin AL, Dibella R, Campbell L, Martin GH, Lemar H, Cayton T, Huang RY, Deng X, Nayeem A, Chen H, Ergel B, Rizzo JM, Yamniuk AP, Dutta S, Ngo J, Shorts AO, Ramakrishnan R, Kozhich A, Holloway J, Fang H, Wang YK, Yang Z, Thiam K, Rakestraw G, Rajpal A, Sheppard P, Quigley M, Bahjat KS, Korman AJ.
VISTA is an acidic pH-selective ligand for PSGL-1.
Nature. 2019 Oct.

Labarthe L, Henriquez S, Lambotte O, Di Santo JP, Le Grand R, Pflumio F, Arcangeli ML, Legrand N, Bourgeois C.
Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF-A2 humanized mice resemble those in human samples.
J Leukoc Biol. 2019 Aug 4.

Rezza A, Jacquet C, Le Pillouer A, Lafarguette F, Ruptier C, Billandon M, Isnard Petit P, Trouttet S, Thiam K, Fraichard A, Chérifi Y.
Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in.
Sci Rep. 2019 Mar 5.

Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC.
Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.
EMBO Rep. 2018 Sep 20.

Ménoret S, Ouisse LH, Tesson L, Delbos F, Garnier D, Remy S, Usal C, Concordet JP, Giovannangeli C, Chenouard V, Brusselle L, Merieau E, Nerrière-Daguin V, Duteille F, Bellier-Waast F, Fraichard A, Nguyen TH, Anegon I.
Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models.
Transplantation. 2018 Apr 24.

Dehairs J, Talebi A, Cherifi Y, Swinnen JV.
CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing.
Sci Rep. 2016 Jul 1.

Renaud JB, Boix C, Charpentier M, De Cian A, Cochennec J, Duvernois-Berthet E, Perrouault L, Tesson L, Edouard J, Thinard R, Cherifi Y, Menoret S, Fontanière S, de Crozé N, Fraichard A, Sohm F, Anegon I, Concordet JP, Giovannangeli C.
Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.
Cell Rep. 2016 Feb 24.

Viuff D, Antunes F, Evans L, Cameron J, Dyrnesli H, Thue Ravn B, Stougaard M, Thiam K, Andersen B, Kjærulff S, Howard KA.
Generation of a double transgenic humanized neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs.
J Control Release. 2016 Feb 10.

Ménoret S, De Cian A, Tesson L, Remy S, Usal C, Boulé JB, Boix C, Fontanière S, Crénéguy A, Nguyen TH, Brusselle L, Thinard R, Gauguier D, Concordet JP, Cherifi Y, Fraichard A, Giovannangeli C, Anegon I.
Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins.
Sci Rep. 2015 Oct 7.

Sothilingam V, Garcia Garrido M, Jiao K, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Koepfli T, Mühlfriedel R, Schön C, Biel M, Heckmann A, Beck SC, Michalakis S, Wissinger B, Seeliger MW, Paquet-Durand F.
Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.
Hum Mol Genet. 2015 Oct 1.

Remy S, Tesson L, Menoret S, Usal C, De Cian A, Thepenier V, Thinard R, Baron D, Charpentier M, Renaud JB, Buelow R, Cost GJ, Giovannangeli C, Fraichard A, Concordet JP, Anegon I.
Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.
Genome Res. 2014 Jul 2.

Ménoret S, Fontanière S, Jantz D, Tesson L, Thinard R, Rémy S, Usal C, Ouisse LH, Fraichard A, Anegon I.
Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases.
FASEB J. 2012 Nov 12. [Epub ahead of print]

Satoh-Takayama N, Vosshenrich CA, Lesjean-Pottier S, Sawa S, Lochner M, Rattis F, Mention JJ, Thiam K, Cerf-Bensussan N, Mandelboim O, Eberl G, Di Santo JP.
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.
Immunity. 2008 Dec 19;29(6):958-70. doi: 10.1016/j.immuni.2008.11.001. Epub 2008 Dec 11.

Cozzi J, Fraichard A, Thiam K.
Use of genetically modified rat models for translational medicine.
Drug Discov Today 2008; 13: 488-494.

Tesson L, Cozzi J, Menoret S, Remy S, Usal C, Fraichard A, Anegon I.
Transgenic modifications of the rat genome.
Transgenic Res. 2005 Oct;14(5):531-46.

Zhou Q, Renard JP, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J.
Generation of fertile cloned rats by regulating oocyte activation.
Science. 2003 Nov 14;302(5648):1179. Epub 2003 Sep 25.

Article in Book:

"Procedures for somatic cell nuclear transfer in the rat" Jean Cozzi, Eryao Wang, Christelle Jacquet, Alexandre Fraichard, Yacine Cherifi, Qi Zhou. Methods and Protocols, Methods in Molecular Biology, vol 597, Humana Press 2010

"Interference RNA for in vivo knock-down of gene expression or genome-wide screening using shRNA". Petit S, Thiam K. In: Anegon (ed.). Rat genomics: Methods and Protocols, Methods in Molecular Biology, vol 597, @ Humana Press 2010

"Pronuclear DNA injection for the production of transgenic rats". Cozzi J, Fraichard A, Braun V, Gross A-C, Merrouche C, Anegon I, Thiam K. In: Transgenesis, Third Edition. 2008

"in vivo RNA interference: another tool in the Box?" in Non-viral Gene Therapy - Gene design and Delivery. Taira, K.; Kataoka, K.; Niidome, T. (Eds.) @ Springer-verlag Tokyo 2005