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Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling
Sci Immunol
Jan 2026
Reversing enhancer RNA–mediated IKBKE gene repression enables synthetic anticancer immunity in prostate cancer models
J Clin Invest
Jan 2026
Efzimfotase Alfa Improves Respiratory Capacity in Muscle Tissue From a Mouse Model of HPP
JIMD Rep
Dec 2025
cGAS-STING signaling in the tumor microenvironment induces myeloid cell activation and favors T cell-mediated antitumor immunity
Cancer Biol Ther
Dec 2025
A homozygous variant in the beta‑1,3‑N‑acetylglucosaminyltransferase 4 gene causes progressive brain atrophy and muscular dystrophy
Eur J Hum Genet
Dec 2025
Loss of C9orf72 impacts the peripheral neuromuscular system via immune dysregulation and accelerates the progression of amyotrophic lateral sclerosis in SOD‑1 mutant mice
J Neuroinflammation
Nov 2025
Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice
Diabetes
Nov 2025
Conditional Atxn2l deletion caused hypoactivity without cell loss and altered expression of splicing-related proteins, supporting a role for ATXN2L in RNA regulation in mature neurons
Cells
Sep 2025
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models
Nat Commun
Sep 2025
Tissue Distribution and Phenotype of Human Mast Cells in BRGSF and NSG-SGM3-IL15 Humanized Mice
Allergy
Sep 2025
Conditionally Active CD28xVISTA Bispecific Antibodies Promote Myeloid‑Driven T‑Cell Activation
Cancer Immunol Res
Sep 2025
Tumor-dependent myeloid and lymphoid cell recruitment in genO-BRGSF-HIS mice: a novel tool for evaluating immune therapies
Front Immunol
Sep 2025
Loss of M1 Acetylcholine Receptor-mediated Orexinergic Activity Contributes to Immune Dysfunction in Experimental Sepsis
Res Sq
Aug 2025
An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release
J Immunother Cancer
Aug 2025
Advancing In Vivo Detection of T‑Cell Function: Development and Preclinical Evaluation of ⁸⁹Zr‑Ivuxolimab, a Human OX40 PET Tracer
J Nucl Med
Jul 2025
Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies
Microbiol Spectr
Jul 2025
ANV600 is a novel PD-1 targeted IL-2Rβγ agonist that selectively expands tumor antigen-specific T cells and potentiates PD-1 checkpoint inhibitor therapy
J Immunother Cancer
Jul 2025
Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction
J Biol Chem
Jun 2025
PET-based immunomapping of intratumoral CD4+ cells to monitor acquired resistance to checkpoint inhibitors
Sci Adv
Jun 2025
Consolidation of cell‑ECM adhesion through direct talin‑mediated actin linkage is essential for mouse embryonic morphogenesis
Commun Biol
Jun 2025
DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46
Neurobiol Dis
Jun 2025
Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis
Acta Neuropathol
Jun 2025
IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell-mediated cytotoxicity of PD-L1 positive tumor cells
Cancer Immunol Res
May 2025
Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells
Nat Commun
May 2025
A Novel B7-H4xCD3 Bispecific T Cell Engager (PF-07260437) Synergizes with Breast Cancer Standard of Care and Immune-Checkpoint Therapies
Mol Cancer Ther
May 2025
Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway
Nat Commun
May 2025
An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models
Nat Commun
May 2025
Reactivation of CTLA4-expressing T cells Accelerates Resolution of Lung Fibrosis in a Humanized Mouse Model
J Clin Invest
Mar 2025
An inducible FOXL2-dependent mouse model of ovarian adult type granulosa cell tumor
Gynecol Oncol
Mar 2025
Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics
PLoS One
Feb 2025
The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice
Alzheimers Res Ther
Jan 2025
NI-3201 Is a Bispecific Antibody Mediating PD-L1-Dependent CD28 Co-stimulation on T Cells for Enhanced Tumor Control
Cancer Immunol Res
Jan 2025
PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451
Biomaterials
Oct 2024
In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy
Theranostics
Aug 2024
Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993
Eur J Nucl Med Mol Imaging
Jul 2024
Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition
Geroscience
Jul 2024
Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia
Invest Ophthalmol Vis Sci
Jun 2024
Missense mutation (C667F) in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization
Dis Model Mech
Jun 2024
An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva
Sci Transl Med
May 2024
A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia
Sci Rep
May 2024
Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution
JCI Insight
May 2024
Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin
JCI Insight
May 2024
Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression
Mol Cancer Ther
May 2024
Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy
Nat Neurosci
May 2024
HPN328, a Trispecific T Cell-activating Protein Construct Targeting DLL3-Expressing Solid Tumors
Mol Cancer Ther
Apr 2024
Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells
J Am Soc Nephrol
Apr 2024
CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors
Clin Cancer Res
Apr 2024
VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response
Nat Commun
Apr 2024
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia
Neurobiol Dis
Mar 2024
Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas
Hum Mol Genet
Mar 2024
Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Nat Cardiovasc Res
Mar 2024
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration
Nat Commun
Mar 2024
Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases
Front Immunol
Feb 2024
NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice
Nat Commun
Feb 2024
An Engineered Mouse Model That Generates a Diverse Repertoire of Endogenous, High-Affinity Common Light Chain Antibodies
Front Immunol
Feb 2024
Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model
Front Immunol
Feb 2024
The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function
Cell Death Dis
Jan 2024
Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice
JBMRplus
Jan 2024
Rational design of a genomically humanized mouse model for dominantly inherited hearing loss, DFNA9
Hear Res
Dec 2023
Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of HDL and LDL in opposite ways
Cardiovasc Res
Dec 2023
Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain
Cell Mol Life Sci
Nov 2023
Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice
Heliyon
Nov 2023
A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors
Front Immunol
Oct 2023
Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer
Cancer Cell
Sep 2023
Cathepsin D overexpression in the nervous system rescues lethality and Ab42 accumulation of cathepsin D systemic knockout in vivo
Acta Pharm Sin B
Sep 2023
Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy
J Allergy Clin Immunol
Sep 2023
PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia
Autophagy
Aug 2023
Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment
Proc Natl Acad Sci U S A
Jun 2023
SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties
Immunohorizons
Jun 2023
Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality
PLoS One
Jun 2023
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion
JCI Insight
May 2023
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling
Nat Commun
Apr 2023
Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice
PLoS One
Mar 2023
NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes
iScience
Mar 2023
Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes
Life Sci Alliance
Mar 2023
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis
Nat Commun
Mar 2023
Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice
PLoS One
Feb 2023
6 good reasons to employ our repository Knockout mouse models in your in vivo studies
Eucomm conditional Knockouts
6 min read
-
Aug 2019
A new Nature report by Bristol-Myers Squibb provides new insights into VISTA biology and design of combination therapies
Humanized ICP in immuno-oncology
3 min read
-
Oct 2019
A finely tuned crosstalk between enteric neurons and muscularis macrophages: evidence from a conditional Knockout mouse model developed by genOway
Customized mouse model
3 min read
-
Jan 2020
A Knockin C3-reporter mouse model represents a valuable tool to monitor C3 levels, a biomarker of inflamed versus uninflamed tissues
Customized mouse model
3 min read
-
Apr 2020
Define “humanized”: two mouse models helping produce cancer immunotherapies
Humanized mouse models
4 min read
-
Nov 2020
A novel preclinical and translational humanized CD3ε model to study the efficacy of T-cell engagers
T-cell engager
8 min read
-
Feb 2021
Uncoupling toxicity from therapeutic efficacy: the new challenge of immunotherapies
Assess toxicity with ICP
3 min read
-
Apr 2021
Uncoupling toxicity from therapeutic efficacy: a case study on ATOR-1015
Bispecific antibodies
5 min read
-
Apr 2021
Tumor grafts in preclinical research: Models, models, overall, who is the fittest of them all?
Tumor-graft models
5 min read
-
Aug 2021
Deciphering high-dose IL-2 toxicity in reconstituted HIS mice
Immunotherapy in BRGSF-HIS
6 min read
-
Aug 2021
The importance of genetic design when choosing your preclinical model - A Case Study on GLP-1R
Physiological relevancy in preclinical models
4 min read
-
Sep 2021
Predictive in vivo evaluation of immunotherapy efficacy: tHIS is a reliable model
PDX in BRGSF-HIS
6 min read
-
Nov 2021
A human-specific modifier of cortical connectivity and circuit function
Customized mouse model
3 min read
-
Nov 2021
NOTUM as alternative therapeutic approach to prevent clonal fixation and mutant expansion in patients predisposed to colorectal cancer
Customized mouse model
3 min read
-
Nov 2021
Immunotherapy efficacy assessment and metastases studies: tHIS model is highly permissive to engraftment
Engraftments in BRGSF-HIS
8 min read
-
Nov 2021
Immunocompromised human serum albumin/human neonatal Fc receptor mouse model: A new xenograft model for efficacy studies of immunotherapies
Therapeutic efficacy and pharmacokinetics
8 min read
-
Jan 2022
Relevant preclinical models to test T-cell engagers: The case of CD28
T-cell engager
5 min read
-
Mar 2022
An alternative approach to immunotherapy: A bispecific agonist
Humanized PD-1 & GITR mouse
4 min read
-
Mar 2022
Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model
T-cell engager CD3
3 min read
-
Mar 2022
Targeting tumor-associated myeloid cells: The new grail in immuno-oncology?
Myeloid compartment in immuno-oncology
3 min read
-
Apr 2022
Challenging the predictability of preclinical models for assessment of T-cell engagers
Assess T-cell engager in BRGSF-HIS
5 min read
-
May 2022
Homeostasis of monocytes and lung interstitial macrophages is regulated by collagen domain-binding receptor LAIR1 in vivo
Myeloid compartment in BRGSF-HIS
6 min read
-
Jun 2022
Assessing T-cell engagers in vivo: How BRGSF-HIS mice can help
Assess T-cell engager in BRGSF-HIS
6 min read
-
Jun 2022
Functional human myeloid compartment in BRGSF-HIS preclinical model
Myeloid compartment in BRGSF-HIS
4 min read
-
Nov 2022
An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension
Humanized HSA/hFcRn mouse
3 min read
-
Nov 2022
Expression of druggable myeloid targets in the BRGSF-HIS preclinical model
Myeloid compartment in BRGSF-HIS
3 min read
-
Mar 2023
Assessing T-cell engagers efficacy in vivo: Versatility of BRGSF-HIS mice
Assess T-cell engager in BRGSF-HIS
3 min read
-
Oct 2023
Targeting myeloid cells in the tumor microenvironment in BRGSF-HIS mice
Myeloid compartment in BRGSF-HIS
7 min read
-
Dec 2023
A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors
Humanized VISTA mouse & Pharmacokinetics
10 min read
-
Dec 2023
Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized genO-BRGSF-HIS preclinical model
CRS in genO-BRGSF-HIS
7 min read
-
Feb 2024
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