Customize a mouse model

Combined PK, efficacy and safety assessment in a single model

Create a customized mouse with the humanized target of your choice on the genO-hSA/hFcRn mouse background for evaluating at the same time PK, efficacy and safety of a therapeutic antibody with hSA and/or hFcRn binding.

For example, we created genO-panhCD3/hSA/hFcRn to assess efficacy and PK of T-cell engagers.

► Learn more about the genO-hSA/hFcRn mouse

Efficacy assessment of Fc-engineered therapeutics

To test both Fab and Fc regions of your Fc-engineered therapeutic in the same model you can customize the genO-hFcγR mouse with your target of choice.

For example, we created the genO-hCCR8/hCCL1/hFcγR to assess anti-hCCR8 antibodies with Fc-competent domain.

► Learn more about the genO-hFcγR mouse

Assess efficacy with reduced anti-drug antibody (ADA) development 

Create a mouse model with a humanized target of choice and tolerance to human IgG1 to accurately assess the efficacy of new therapeutics while reducing ADA responses.

For example, we created genO-panhCD3/hIgG1 to assess efficacy of IgG1-based T-cell engagers.

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Our strengths on custom-made model creation

• 25 years of proven track record in developing custom-made models
• In-depth analysis of the project to design a model fully adapted to your research, with strategic selection of gene engineering technology
• Models delivered with all IP rights necessary for your activity
• Milestone-based billing for budget management