Reconstituted Mouse & Rat Strain Portfolio
Immunodeficient humanized mouse models offer new opportunities to address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.
Our BRGSF mice are excellent recipients for human hematopoietic cells. We routinely generate BRGSF-HIS (humanized for the immune system) mice, using human CD34+ hematopoietic progenitor cells.
The BRGSF-HIS mice contain all major human hematopoietic cell subsets, such as B cells, T cells (including CD4+ Treg cells), NK cells, and the myeloid compartment including dendritic cells (DCs), plasmacytoid cells (pDCs) and monocytes/macrophages.
The BRGSF-A2-HIS model is generated by inserting an human leukocyte antigen serotype A2 (HLA-A2) class I transgene in the genome of BRGSF (BALB/c Rag2tm1Fwa Il2rgtm1Cgn SirpaNOD Flt3tm1lrl) mice, and subsequently reconstituted with a functional human immune system (HIS).