This reliable Foxp3 reporter mouse model allows you to efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs, and represents a powerful drug testing tool to:

  • Study the modulation of the immune tolerance mechanism in autoimmune diseases
  • Treat cancers via immune checkpoint inhibitor discovery

Model features

Foxp3 is the regulatory T cell-specific transcription factor that functions as the master regulator of the development and function of regulatory T cells.
This Foxp3-IRES-mRFP (FIR) mouse model provides access to direct in vivo detection of Foxp3-expressing cells.

In contrast to other existing Foxp3 models generated by random insertion, this Knockin mouse line preserves physiological expression of Foxp3 and enables monitoring of endogenous Foxp3.

No deregulation of endogenous Foxp3 expression:

  • Endogenous Foxp3 is expressed and functional: reporter gene inserted in the 3'UTR of the endogenous Foxp3 locus
  • The genetic manipulation inserted is controlled
  • Reporter faithfully mirrors Foxp3 expression

Suitable model for your Treg studies:

  • Foxp3-expressing cells can be directly detected by monitoring mRFP expression (Fig. 1)
  • Uncompromised immune system: intact function of Treg cells (Fig. 2)
  • Optimum monitoring of Treg cells trafficking and cell sorting

Validation

Related ressources et publications

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